Shifts in intestinal microbiota after duodenal exclusion favor glycemic control and weight loss: a randomized controlled trial

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
Ramon V CortezCarla R Taddei

Abstract

In recent years, studies indicate gut microbiota as an important modulator in the pathophysiology of type 2 diabetes. Environmental and genetic factors interact to control the host's intestinal microbiota, triggering metabolic disorders such as obesity and insulin resistance. The objective of this study was to identify the fecal microbiota in adult type 2 diabetes patients and to assess changes in composition after metabolic surgery. University Hospital of the University of São Paulo. Twenty-one patients were enrolled in a randomized controlled study divided into 2 arms. One group underwent duodenal-jejunal bypass surgery with minimal gastric resection, and fecal samples were collected before the operation and after 6 and 12 months. The other group received medical care (standard care group) and was followed for 12 months. Fecal samples were collected at baseline and after 6 and 12 months. Fecal microbiota was analyzed using high-throughput sequencing with V4 16 S rRNA primers. The fecal microbiota in duodenal-jejunal bypass surgery with minimal gastric resection group (Bacteroides, Akkermansia, and Dialister) exhibited increased abundance and diversity compared with that in the standard care group; however, the increase in A. ...Continue Reading

Citations

Mar 20, 2019·Current Gastroenterology Reports·Maya FayfmanShanthi Srinivasan
Apr 15, 2019·Obesity Surgery·Josianne C H B M LuijtenMisha D P Luyer
Apr 30, 2020·Nutrients·Silke CrommenMarie-Christine Simon
Nov 3, 2020·Food Science & Nutrition·Viviano Gomes de Oliveira NevesRenata Guerra-Sá
Jul 22, 2021·Reviews in Endocrine & Metabolic Disorders·Carolina Gutiérrez-RepisoFrancisco J Tinahones

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