Shigella IpaH Family Effectors as a Versatile Model for Studying Pathogenic Bacteria

Frontiers in Cellular and Infection Microbiology
Hiroshi Ashida, Chihiro Sasakawa

Abstract

Shigella spp. are highly adapted human pathogens that cause bacillary dysentery (shigellosis). Via the type III secretion system (T3SS), Shigella deliver a subset of virulence proteins (effectors) that are responsible for pathogenesis, with functions including pyroptosis, invasion of the epithelial cells, intracellular survival, and evasion of host immune responses. Intriguingly, T3SS effector activity and strategies are not unique to Shigella, but are shared by many other bacterial pathogens, including Salmonella, Yersinia, and enteropathogenic Escherichia coli (EPEC). Therefore, studying Shigella T3SS effectors will not only improve our understanding of bacterial infection systems, but also provide a molecular basis for developing live bacterial vaccines and antibacterial drugs. One of Shigella T3SS effectors, IpaH family proteins, which have E3 ubiquitin ligase activity and are widely conserved among other bacterial pathogens, are very relevant because they promote bacterial survival by triggering cell death and modulating the host immune responses. Here, we describe selected examples of Shigella pathogenesis, with particular emphasis on the roles of IpaH family effectors, which shed new light on bacterial survival strategie...Continue Reading

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Aug 31, 2016·Nature Microbiology·Ilan Rosenshine
Oct 18, 2016·Frontiers in Molecular Biosciences·Maria Letizia Di MartinoGianni Prosseda
Jan 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alexander F A Keszei, Frank Sicheri
Dec 21, 2017·Frontiers in Microbiology·Martina PasquaGianni Prosseda
May 10, 2017·Journal of Cell Science·Yi-Han Lin, Matthias P Machner
Sep 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Dylan ValleauAlexei Savchenko
Apr 5, 2020·Toxins·Hélène Bierne, Renaud Pourpre
Oct 30, 2020·Frontiers in Cellular and Infection Microbiology·Xiaolin WangCongwen Wei
Apr 7, 2019·Microbiology Spectrum·Pamela Schnupf, Philippe J Sansonetti
Jul 24, 2021·Journal of Medical Microbiology·Jin SunCongwen Wei
May 30, 2019·ACS Central Science·Morgan B LudwickiMatthew P DeLisa
Sep 16, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Fatima Bachir HalimehMonzer Hamze

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Methods Mentioned

BETA
ubiquitination
PMA
nuclear translocation

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