Shish-kebab-structured poly(ε-caprolactone) nanofibers hierarchically decorated with chitosan-poly(ε-caprolactone) copolymers for bone tissue engineering

ACS Applied Materials & Interfaces
Xin JingLih-Sheng Turng

Abstract

In this work, scaffolds with a shish-kebab (SK) structure formed by poly(ε-caprolactone) (PCL) nanofibers and chitosan-PCL (CS-PCL) copolymers were prepared via electrospinning and subsequent crystallization for bone tissue engineering applications. The aim of this study was to introduce nanosized topography and the high biocompatibility of chitosan onto PCL nanofibers to enhance cell affinity to PCL scaffolds. CS-PCL copolymers with various ratios were synthesized, and then spontaneously crystallized as kebabs onto the electrospun PCL fibers, which acted as shishes. Scanning electron microscopy (SEM) results demonstrated that the copolymer with PCL to chitosan ratio of 8.8 could hierarchically decorate the PCL nanofibers and formed well-shaped kebabs on the PCL nanofiber surface. Water contact angle tests and biomimetic activity experiments revealed that the shish-kebab scaffolds with CS-PCL kebabs (PCL-SK(CS-PCL(8.8))) showed enhanced hydrophilicity and mineralization ability compared with smooth PCL and PCL-SK(PCL) shish-kebab scaffolds. Osteoblast-like MG63 cells cultured on the PCL-SK(CS-PCL(8.8)) scaffolds showed optimizing cell attachment, cell viability, and metabolic activity, demonstrating that this kind of scaffold h...Continue Reading

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Citations

Feb 16, 2017·Journal of Biomedical Materials Research. Part a·Xi ChenChristopher Y Li
Feb 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Justina Roxana VirlanMaria Greabu
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Nov 25, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao-Yang MiLih-Sheng Turng
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Jul 23, 2019·ACS Applied Materials & Interfaces·Sarah YahiaIbrahim M El-Sherbiny

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