Shock stress protects mice against amphetamine-induced dopaminergic toxicity

Brain Research
Kirsten M Carlson, George C Wagner

Abstract

The effect of tail shock (ten, 2.0 mA/0.15 s shocks) on amphetamine-induced dopaminergic toxicity in adult, male BALB/c mice was assessed. Fifteen minutes following a single shock session, mice received amphetamine (50-mg/kg) or saline as follows: Shock/Saline; NoShock/Saline; Shock/Amphetamine; No Shock/Amphetamine. Amphetamine caused a 60% dopamine depletion in the No Shock/Amphetamine group. Tail shock provided neuroprotection against amphetamine-induced dopamine depletion, an effect likely related to the stress response.

References

Aug 1, 1977·Journal of Comparative and Physiological Psychology·J W HennessyS Levine
Jan 10, 1998·Physiology & Behavior·M A ColemanP A Carter
May 5, 1998·Molecular and Chemical Neuropathology·C S MyersG C Wagner
Jun 18, 2003·Endocrinology·Susanne K DrosteJohannes M H M Reul
Dec 9, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhizhong DongHansruedi Büeler
Apr 27, 2005·Brain Research. Brain Research Reviews·Bianca MarchettiMaria Concetta Morale
Oct 8, 2005·The Journal of Biological Chemistry·Hai-Ying ShenJiang-Fan Chen
Oct 20, 2005·Journal of Neuroscience Research·Guo-Hua FanSheng-Di Chen

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