Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

Annals of Vascular Surgery
Jiunn-Jye SheuHon-Kan Yip

Abstract

We tested whether shock wave (SW) offers additional benefits in improving left ventricular (LV) function after acute myocardial infarction (AMI) in rabbits receiving SW-treated autologous bone marrow-derived mononuclear cells (BMDMNCs) transplantation. Saline (750 microL; group 2), BMDMNCs (1.0 x 10(7); group 3), or preimplant SW-treated BMDMNCs (group 4) were implanted into the infarct area of male rabbits 15 minutes after left coronary artery ligation, whereas eight rabbits without AMI served as controls (group 1; n = 8 per group). The results showed that in infarct area of LV, protein expressions of Cx43 and cytochrome C in mitochondria and endothelial nitric oxide synthase mRNA expression were lower in group 2 than in other groups, and decreased in group 3 as compared with groups 1 and 4 (all p values < 0.01). Conversely, mRNA expressions of endothelin-1 and matrix metalloproteinase-9, mitochondrial oxidative stress, and total fibrotic area were higher in group 2 than in other groups (all p values < 0.05). Furthermore, 6-month LV function by 2-D echo/angiogram showed significant impairment in group 2 than in other groups and in group 3 than in groups 1 and 4 (all p values < 0.005). Application of SW-treated autologous BMDMN...Continue Reading

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Citations

Mar 22, 2012·Journal of Orthopaedic Surgery and Research·Ching-Jen Wang
Jun 7, 2014·Canadian Journal of Physiology and Pharmacology·Srikanth GivvimaniSuresh C Tyagi
Aug 8, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenta Ito, Hiroaki Shimokawa
Jan 4, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Gianluca AlunniAmir Lerman
Jul 15, 2016·American Journal of Physiology. Cell Physiology·Kazuaki HatanakaHiroaki Shimokawa
Aug 19, 2011·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Kenta ItoHiroaki Shimokawa
Nov 23, 2011·Expert Review of Cardiovascular Therapy·Yuan Liu, Hung-Fat Tse
Oct 3, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuzuru AbeHiroaki Shimokawa

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