Shooting the messenger: RNA-targetting CRISPR-Cas systems

Bioscience Reports
Yifan ZhuRaymond H J Staals

Abstract

Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-associated genes) immune systems, astonishing progress has been made on revealing their mechanistic foundations. Due to the immense potential as genome engineering tools, research has mainly focussed on a subset of Cas nucleases that target DNA. In addition, however, distinct types of RNA-targetting CRISPR-Cas systems have been identified. The focus of this review will be on the interference mechanisms of the RNA targetting type III and type VI CRISPR-Cas systems, their biological relevance and their potential for applications.

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Citations

Oct 2, 2019·Frontiers in Microbiology·Nicolás ToroAlejandro González-Delgado
Mar 12, 2019·Frontiers in Microbiology·Shweta JaiswalPratyoosh Shukla
Feb 13, 2020·International Journal of Molecular Sciences·Michal BurmistrzAgata Krawczyk-Balska
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Nov 4, 2020·Science China. Life Sciences·Zhenxiao YuQunxin She
Mar 2, 2021·Frontiers in Bioengineering and Biotechnology·Sandhya MishraShaohua Chen
May 3, 2021·Methods : a Companion to Methods in Enzymology·Shaochong ZhangDong Fang

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Software Mentioned

PSI
BLAST
HHpred

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