Short- and intermediate-term carcinogenicity testing--a review. Part 2: available experimental models

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Harald G EnzmannG M Williams

Abstract

Numerous experimental protocols for short- and intermediate-term carcinogenicity assays have been available for many years. This paper surveys various of these test systems in rodents, fish species, non-vertebrates and avian embryos in ovo. The mouse skin tumour assay and the rat liver foci assay were used to introduce the basic concepts of short- and intermediate-term carcinogenicity testing in the previous part of the review. The focus of this second part of the review is on rodent assays for carcinogenicity testing in the lung, kidney, urinary bladder, pancreas, stomach, oral cavity, small intestine, colon, and on the possibility to combine several target organs in multi-organ models. The potential use of various fish species, non-vertebrates and hatching eggs for carcinogenicity testing is outlined and the advantages and limitations are discussed. This review also presents the problem of validation of any carcinogenicity test system and proposes a strategy for contemporary safety assessment of chemicals with regard to the detection and evaluation of carcinogenicity.

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Citations

Feb 18, 2011·Archives of Toxicology·J G WilliamsG M Williams
Sep 24, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Harald G EnzmannGary M Williams
Jul 27, 2001·Mutation Research·G SelloE Benfenati
Nov 6, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·H EnzmannG Williams
Aug 30, 2013·Critical Reviews in Toxicology·David A EastmondBabasaheb Sonawane
Nov 30, 2013·Regulatory Toxicology and Pharmacology : RTP·Palma Ann MaroneA Wallace Hayes
Oct 5, 2010·International Journal of Toxicology·Peter J BugelskiJacques Descotes

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