Short- and long-term effects of L-dopa administration on striatal acetylcholinesterase activity

Molecular and Chemical Neuropathology
M Messripour, Z Shahidi

Abstract

Exogenously applied dopamine may interfere with cholinergic activity in the brain. The aim of the present work was to study the effect of L-dopa administration on acetylcholinesterase (EC 3.1.1.7) activity in rat (Wistar) brain striatum. Short-term administration of a mixture of L-dopa (10 mg/kg) and carbidopa (1 mg/kg) resulted in an increase in dopamine content and a decrease in acetylcholinesterase activity of the tissue. The greatest changes were found 30 min postinjection, and activity returned to near-control values after 2 h. When the drug mixture was injected for a period of 30 d and the animals were killed 24 h after the last injection, a lower dopamine content and higher enzyme activity were seen, compared to control values. It would appear that chronic administration of L-dopa gradually reduced the dopamine-storage capacity of the striatum and that the activity of acetylcholinesterase might be controlled by the levels of dopamine in the brain striatum.

References

May 1, 1974·The Journal of Physiology·N Dun, S Nishi
Jul 1, 1974·Journal of Neurochemistry·R L Patrick, J D Barchas
Jan 1, 1974·Journal of Psychiatric Research·A Randrup, I Munkvad
Jul 26, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A Philippu, J Beyer
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Jan 1, 1985·Neurochemistry International·M Messripour, J B Clark

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Citations

Mar 1, 2019·Investigative Ophthalmology & Visual Science·Christine F WildsoetJames S Wolffsohn
Mar 17, 2004·Phytotherapy Research : PTR·Bala V ManyamTheodore A Hare

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