PMID: 6969626Dec 15, 1980Paper

Short- and long-term effects of radiation on T-cell subsets in peripheral blood of patients with Hodgkin's disease

Cancer
S RomagnaniM Ricci

Abstract

The present study was undertaken to determine the effect of radiotherapy on subpopulations of peripheral blood T cells from patients with Hodgkin's disease. T cell were purified from each specimen, and proportions and absolute numbers of T lymphocytes bearing receptors for the Fc portion of IgG (TG) and for Fc portion of IgM (TM) were enumerated by rosetting T cells with ox red blood cells (ORBC), which had been coated with anti-ORBC rabbit IgG or IgM, respectively. In untreated patients, the percentage of TG cells was significantly increased, and the percentage of TM cells was significantly decreased when compared with control values. In patients examined after radiotherapy, there was a severe depletion of total T lymphocytes. The percent and absolute values of TM cells were also markedly decreased in comparison with those found in either normal controls or untreated patients. In contrast, relative proportions of TG cells were significantly increased in the same treated patients, but the absolute numbers of these cells were essentially unchanged in comparison with those found before radiation therapy. There was a partial and progressive restoration of the number of TM lymphocytes some years after the treatment, but reduced per...Continue Reading

References

Jan 1, 1979·Immunological Reviews·R E BallieuxB J Zegers
Aug 1, 1975·The Journal of Clinical Investigation·J J TwomeyC C Douglass
Jan 1, 1977·International Archives of Allergy and Applied Immunology·S RomagnaniM Ricci
Jun 1, 1978·The Journal of Clinical Investigation·S M Hillinger, G P Herzig
Dec 2, 1976·The New England Journal of Medicine·Z FuksH S Kaplan
Jan 1, 1978·The Journal of Clinical Investigation·W L SibbittR C Williams
Jan 1, 1978·Scandinavian Journal of Immunology·S RomagnaniM Ricci
Jan 1, 1979·Immunological Reviews·L MorettaA Moretta
Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
Jan 1, 1975·European Journal of Immunology·M FerrariniM L Durante
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Jan 1, 1974·Scandinavian Journal of Haematology·E Andersen

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Citations

Oct 1, 1981·International Journal of Radiation Oncology, Biology, Physics·K E EkstrandM Raben
Sep 1, 1985·Cancer·G T GowittL T Heffner
Feb 1, 1982·Scandinavian Journal of Haematology·F CozzolinoR Di Guglielmo
Oct 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W C GrayJ V Ordonez

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