Short- and long-term effects of secretin and a cholecystokinin-like peptide on pancreatic growth and synthesis of RNA and polyamines.

Scandinavian Journal of Gastroenterology
H Haarstad, H Petersen

Abstract

Little is known about the cellular mechanisms responsible for the trophic effects of cholecystokinin (CCK) and secretin on the rat pancreas, and controversy exists with regard to the interaction between these two peptides. In the present study attempts were made to elucidate the time course of events leading to pancreatic growth and to clarify the interaction between the peptides when given as continuous, long-term intravenous infusions to rats. A cholecystokinin-like peptide (CCK-LP) and secretin were given as a continuous intravenous infusion to conscious and unrestrained animals with free access to food and water for 0.5, 1, 2, 4, 6, 8, 12, 24, 48, and 96 h. The pancreas was quickly removed and analyzed for variables indicating synthesis and accumulation of DNA, RNA, and polyamines. CCK-LP increased the activity of RNA polymerase already after 1 h, whereas an increase in the activity of ornithine decarboxylase (ODC) and the level of putrescine was seen at 4 h. Spermidine was increased after 12 h. The activities of DNA polymerase and thymidine kinase were increased at 12 and 24 h, respectively, whereas the total contents of DNA and RNA were first increased at 48 h. Secretin alone showed a marked but short-lived effect on poly...Continue Reading

References

Feb 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·A P Majumdar
Jan 1, 1978·Scandinavian Journal of Gastroenterology·U R FölschK G Wormsley
Nov 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·D L MainzP D Webster
May 1, 1985·Scandinavian Journal of Gastroenterology·H HaarstadH Petersen
Jan 1, 1985·The International Journal of Biochemistry·D G Blair
Dec 11, 1974·The American Journal of Physiology·O Black, P D Webster
Sep 1, 1973·The Journal of Clinical Investigation·D L MainzP D Webster
Jul 1, 1967·The American Journal of Physiology·S S Rothman, H Wells
Oct 1, 1984·Regulatory Peptides·O Benrezzak, J Morisset
Jan 1, 1983·Advances in Enzyme Regulation·D H Russell
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Dec 10, 1984·Life Sciences·J Morisset, O Benrezzak
Nov 1, 1982·The American Journal of Physiology·A E Pegg, P P McCann
Dec 31, 1982·Biochemical and Biophysical Research Communications·C DanzinJ Grove
Jan 1, 1980·Endocrinology·A B Dembinski, L R Johnson

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Citations

Oct 4, 1995·Molecular and Cellular Biochemistry·P C Lee
Jun 18, 1998·British Journal of Pharmacology·A K SandvikH L Waldum
Sep 1, 2005·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Markus SchweigerWerner M Amselgruber
Jun 21, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Birol BaysalDeniz Tunçel
Oct 3, 2015·Chaos·Elizabeth Bradley, Holger Kantz
Jan 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Bo-Guang Fan
May 1, 1997·Scandinavian Journal of Gastroenterology·A K SandvikH I Waldum
May 1, 1991·Molecular and Cellular Endocrinology·G ScalabrinoM E Ferioli
Oct 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C LöserU R Fölsch
Aug 31, 2021·World Journal of Gastrointestinal Oncology·Lumir KunovskyJan Trna

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