Short- and long-term effects of spirapril on renal hemodynamics in patients with essential hypertension

Journal of Clinical Pharmacology
G P ReamsJ H Bauer

Abstract

Sixteen essential hypertensive patients were entered into a protocol assessing the effect of Spirapril, an angiotensin-converting enzyme (ACE) inhibitor, on blood pressure, the renin-aldosterone system, and renal function. Specifically monitored before, during 6 weeks, and 6 months of Spirapril therapy were plasma renin activity, plasma aldosterone, serum ACE, the renal clearances of creatinine, inulin, and para-aminohippurate, and urinary albumin excretion. Blood pressure was well controlled. Spirapril stimulated plasma renin activity and suppressed ACE throughout the entire protocol. Renal clearances were unchanged. Renal vascular resistance was decreased. Urinary albumin excretion was decreased. The authors conclude that the ACE inhibitor, Spirapril, when used as an effective antihypertensive agent, preserves renal function, lowers renal vascular resistance, and decreases urinary albumin excretion.

References

Nov 1, 1977·The Biochemical Journal·J W RyanM L Carlton
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A H van den MeirackerM A Schalekamp
Jun 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G P Reams, J H Bauer
Oct 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J H Bauer, P Gaddy
Dec 5, 1985·The New England Journal of Medicine·K Godfrey
Jul 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J H Bauer, L B Jones
Nov 1, 1982·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J H BauerR N Burch

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Citations

Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Irena Duka, George Bakris
Dec 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S BianchiV M Campese

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