Short- and long-term efficacy of electroconvulsive stimulation in animal models of depression: The essential role of neuronal survival

Brain Stimulation
Julie JonckheereSylvie Gory-Fauré

Abstract

Severe and medication-resistant psychiatric diseases, such as major depressive disorder, bipolar disorder or schizophrenia, can be effectively and rapidly treated by electroconvulsive therapy (ECT). Despite extensive long-standing clinical use, the neurobiological mechanisms underlying the curative action of ECT remain incompletely understood. Unravel biological basis of electroconvulsive stimulation (ECS) efficacy, the animal equivalent of ECT. Using MAP6 KO mouse, a genetic model that constitutively exhibits features relevant to some aspects of depression; we analyzed the behavioral and biological consequences of ECS treatment alone (10 stimulations over a 2-week period) and associated with a continuation protocol (2 stimulations per week for 5 weeks). ECS treatment had a beneficial effect on constitutive behavioral defects. We showed that behavioral improvement is associated with a strong increase in the survival and integration of neurons born before ECS treatment. Retroviral infection revealed the larger number of integrated neurons to exhibit increased dendritic complexity and spine density, as well as remodeled synapses. Furthermore, our results show that ECS triggers a cortical increase in synaptogenesis. A sustained ne...Continue Reading

Citations

Mar 28, 2020·The International Journal of Neuropsychopharmacology·Fenghua ChenJens R Nyengaard
Oct 24, 2019·ELife·Miklos ArgyelanChristopher Abbott
Mar 11, 2020·Frontiers in Psychology·Ming LiRanji Cui
Aug 29, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Milenna T van DijkArdesheer Talati
May 25, 2021·Frontiers in Molecular Neuroscience·Camille CuveillierAnnie Andrieux
Jun 14, 2021·Brain Stimulation·Gregor GryglewskiPia Baldinger-Melich
Jul 25, 2021·International Journal of Molecular Sciences·Julia LeschikAntonietta Gentile

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