Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam--a pilot study

Critical Care Medicine
Peter V SackeyPeter J Radell

Abstract

To compare memories from the intensive care unit (ICU) and short- and long-term psychological morbidity in patients after sedation with intravenous midazolam or inhaled isoflurane. Prospective long-term follow-up after randomized controlled trial. General ICU at Karolinska University Hospital, Solna, Stockholm. Forty patients in need of sedation during ventilator treatment. Patients were randomized to receive isoflurane or midazolam for goal-directed sedation until extubation or for a maximum of 96 hrs. For short-term follow-up, doctors', nurses', and physiotherapists' notes from the 4 days following exposure to the study drugs were reviewed for words indicating adequate or pathologic cognitive and psychological recovery. For long-term follow-up, all 6-month survivors received questionnaires including the ICU Memory Tool (ICU-MT), Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), and Well-Being Index. Additionally, several screening questions for previous posttraumatic stress symptoms were included. In the short term follow-up, no significant differences were found between groups. In the long-term follow-up, a trend toward fewer hallucinations/delusions after isoflurane sedation than after midazolam (tw...Continue Reading

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References

May 1, 1979·Intensive Care Medicine·J JonesB W Ellis
May 1, 1979·Psychosomatic Medicine·M HorowitzW Alvarez
May 13, 1989·BMJ : British Medical Journal·K L KongC Prys-Roberts
Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·L Weisaeth
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 1, 1996·Psychotherapy and Psychosomatics·P BechK S Johansen
May 18, 2000·The New England Journal of Medicine·J P KressJ B Hall
Aug 2, 2000·Critical Care Medicine·J M EddlestonE Guthrie
Feb 13, 2001·Anaesthesia·P ScraggN Fauvel
Aug 9, 2001·British Journal of Anaesthesia·H M SolimanJ L Vincent
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America
Jun 13, 2002·Acta Anaesthesiologica Scandinavica·Anetth I R Granberg AxèllD B A Lundberg
Sep 10, 2003·Intensive Care Medicine·Brian H CuthbertsonJudith Scott
Aug 19, 2004·Acta Anaesthesiologica Scandinavica·P GuldbrandUNKNOWN Scandinavian Critical Care Trials Group
Jan 11, 2005·Critical Care Medicine·Peter V SackeyPeter J Radell
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Andreas Meiser, H Laubenthal
Aug 10, 2005·Dementia and Geriatric Cognitive Disorders·Franklin Santana SantosMaria Eriksdotter Jonhagen
May 11, 2006·Psychosomatics·Jens Christian RichterFrank-Gerald Pajonk

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Citations

Mar 30, 2011·Intensive Care Medicine·David Bracco, Francesco Donatelli
Oct 29, 2010·Current Psychiatry Reports·O Joseph Bienvenu, Karin J Neufeld
Apr 24, 2008·Critical Care Medicine·Peter J Papadakos
Oct 22, 2011·American Journal of Respiratory and Critical Care Medicine·Shruti B Patel, John P Kress
Mar 21, 2013·Critical Care : the Official Journal of the Critical Care Forum·Anders C GüntherPeter V Sackey
Nov 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Peter V Sackey
Mar 16, 2012·Respiratory Care·David A TurnerScot T Bateman
Mar 17, 2012·Scandinavian Cardiovascular Journal : SCJ·Jan HellströmPeter V Sackey
Jan 19, 2016·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Leanne M AitkenJanice Rattray
Jul 24, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Elena BignamiAlberto Zangrillo
Mar 11, 2015·Critical Care Medicine·Angela JerathUNKNOWN Perioperative Anesthesia Clinical Trials Group
Feb 6, 2015·Critical Care Medicine·Ann M ParkerDale M Needham
Jan 1, 2009·Biochemical and Biophysical Research Communications·Pravat K Mandal, Vincenzo Fodale
Dec 3, 2015·European Journal of Anaesthesiology·Peter Sackey
Aug 28, 2010·International nursing review·P KiekkasG I Baltopoulos
Mar 24, 2016·American Journal of Respiratory and Critical Care Medicine·Angela JerathNiall D Ferguson
Nov 4, 2017·Journal of Clinical Monitoring and Computing·Panumart Manatpon, W Andrew Kofke
Jul 10, 2018·Critical Care Medicine·Lotte KokDieuwke S Veldhuijzen
Sep 23, 2016·Journal of Neurosurgical Anesthesiology·Timothy P DeYoungWilliam A Kofke
Mar 9, 2013·Critical Care Nursing Quarterly·Eddie Maraboto
Jan 1, 2014·Health Psychology and Behavioral Medicine·Mette RatzerAsk Elklit
Jan 1, 2008·Psychosomatik Und Konsiliarpsychiatrie·Kapfhammer Hans-Peter
Jun 24, 2021·Journal of Clinical Nursing·Kristin HalvorsenThomas Eriksson

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