Short- and long-term mortality after liver transplantation in patients with and without hepatocellular carcinoma in the UK.

The British Journal of Surgery
David WallaceJan van der Meulen

Abstract

The increasing demand for liver transplantation has led to considerable changes in characteristics of donors and recipients. This study evaluated the short- and long-term mortality of recipients with and without hepatocellular carcinoma (HCC) in the UK between 1997 and 2016. First-time elective adult liver transplant recipients in the UK were identified and four successive eras of transplantation were compared. Hazard ratios (HRs) comparing the impact of era on short-term (first 90 days) and longer-term (from 90 days to 5 years) mortality were estimated, with adjustment for recipient and donor characteristics. Some 1879 recipients with and 7661 without HCC were included. There was an increase in use of organs donated after circulatory death (DCD), from 0 per cent in era 1 to 35·2 per cent in era 4 for recipients with HCC, and from 0·2 to 24·1 per cent for non-HCC recipients. The 3-year mortality rate decreased from 28·3 per cent in era 1 to 16·9 per cent in era 4 (adjusted HR 0·47, 95 per cent c.i. 0·35 to 0·63) for recipients with HCC, and from 20·4 to 9·3 per cent (adjusted HR 0·44, 0·36 to 0·53) for those without HCC. Comparing era 4 with era 1, improvements were more marked in short-term than in long-term mortality, both fo...Continue Reading

References

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Citations

Aug 7, 2020·JAMA Surgery·Austin D Schenk, W Kenneth Washburn
May 29, 2020·The British Journal of Surgery·S J Wigmore
May 13, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Tommy IvanicsGonzalo Sapisochin
Aug 4, 2021·Transplant Immunology·Ricky Sinharay, William J H Griffiths
Sep 7, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Gillian BriggsDeepak Joshi

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