Short- and medium-term reproducibility of gastric emptying of a solid meal determined by a low dose of 13C-octanoic acid and nondispersive isotope-selective infrared spectrometry

World Journal of Gastroenterology : WJG
Anna Kasicka-JonderkoBarbara Błońska-Fajfrowska

Abstract

To evaluate the reproducibility of a modified 13C breath test-based measurement of solid phase gastric emptying (GE) within the frames of a simple-repeated measure study protocol. Twelve healthy subjects (6 females and 6 males, mean age 24.9+/-0.7 years) were recruited to undergo three identical GE examinations. In six subjects the first two examinations were performed 2 d apart, and the third session was carried out at a median interval of 19.5 d (range 18-20 d) from the second one. In another six subjects the first two measurements were taken 20 d apart (median, range: 17-23 d), whereas the third session took place 2 d after the second one. Probes of expiratory air collected before and during six hours after intake of a solid meal (378 kcal) labelled with 75 microL (68 mg) 13C-octanoic acid, were measured for 13CO2 enrichment with the nondispersive isotope-selective infrared spectrometry NDIRS apparatus. Taking coefficients of variation for paired examinations into account, the short-term reproducibility of the GE measurement was slightly but not significantly better than the medium-term one: 7.7% and 11.2% for the lag phase (T-Lag), 7.3% and 10.9% for the gastric half emptying time (T1/2). The least differences in GE paramet...Continue Reading

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Jul 29, 2005·Journal of Gastroenterology and Hepatology·Krzysztof JonderkoBarbara Błońska-Fajfrowska

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Citations

Apr 21, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Anna Kasicka-JonderkoBarbara Blonska-Fajfrowska
Feb 27, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B Krusiec-Swidergoł, K Jonderko
Aug 19, 2008·Journal of Gastroenterology·Piotr KocełakMałgorzata Szymszal
Mar 30, 2007·Digestive Diseases and Sciences·Anna Kasicka-JonderkoBarbara Błońska-Fajfrowska
Sep 3, 2008·Isotopes in Environmental and Health Studies·Anna Kasicka-JonderkoBarbara Błonska-Fajfrowska
May 7, 2010·Scandinavian Journal of Gastroenterology·Miriam E Clegg, Amir Shafat
Feb 20, 2013·Journal of Gastroenterology·Anna Kasicka-JonderkoPatrycja Mgłosiek
Aug 30, 2008·Expert Opinion on Drug Delivery·Dhaivat C Parikh, Avani F Amin

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