Short- and mid-term repeatability of macular pigment optical density measurements using spectral fundus reflectance.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Nikolaus DragostinoffLeopold Schmetterer

Abstract

Several methods have been proposed for measuring macular pigment optical density (MPOD). To date, none of the realized techniques can be considered as "gold standard". A key issue for the clinical applicability of a method is its repeatability. In this study, we investigated short- and mid-term repeatability of MPOD measurements using reflectometry. A total of 12 healthy young subjects were measured 5 times on 5 consecutive days. Repeatability over 6 months was investigated in patients with AMD. The data in AMD patients were taken from a recently published placebo controlled study investigating the effect of lutein supplementation on MPOD (n = 37; [1]). Four measurements over 6 months were used to calculate repeatability. Spectral fundus reflectance of the fovea was measured in a 2.3° detection field with a custom-built fundus reflectometer. Calculation of MPOD was based on a previously published fundus reflectance model. The coefficients of variation were 6.2 ± 2.4% and 8.0 ± 5.5% in the healthy and AMD group, respectively. Bland-Altman plots indicate that the difference between measurements at day 1 and day 5 in healthy subjects and day 1 and month 6 in AMD patients was small. The maximum deviation in MPOD in a healthy subjec...Continue Reading

References

Oct 18, 2000·Survey of Ophthalmology·S BeattyM Boulton
Jun 8, 2001·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·F C DeloriS A Burns
Aug 23, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Henrike WüstemeyerSebastian Wolf
Jan 13, 2004·Journal of Biomedical Optics·Werner Gellermann, Paul S Bernstein
Sep 17, 2004·Archives of Biochemistry and Biophysics·Tos T J M Berendschot, Dirk van Norren
Apr 5, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cornelia JahnSebastian Wolf
Jul 19, 2005·Experimental Eye Research·Tos T J M Berendschot, Dirk van Norren
Nov 7, 2006·Experimental Eye Research·John M NolanStephen Beatty
Jan 11, 2007·Journal of Biomedical Optics·Jan van de KraatsDirk van Norren
Sep 12, 2007·Archives of Ophthalmology·UNKNOWN Age-Related Eye Disease Study Research GroupRobert D Sperduto
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Stephen BeattyUsha Chakravarthy
May 13, 2008·The American Journal of Clinical Nutrition·Elizabeth J JohnsonD Max Snodderly
Jun 14, 2008·The New England Journal of Medicine·Rama D JagerJoan W Miller
Jun 12, 2009·Retina·Sharon D SolomonUNKNOWN SST research group and the SST adverse event review committee
Mar 2, 2010·BMJ : British Medical Journal·Usha ChakravarthyPhilip J Rosenfeld
Jul 6, 2010·Archives of Biochemistry and Biophysics·Richard A Bone, John T Landrum
Oct 21, 2010·Expert Reviews in Molecular Medicine·Sam Khandhadia, Andrew Lotery
Nov 13, 2010·Investigative Ophthalmology & Visual Science·Yuzuru SasamotoKohji Nishida
Jan 12, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Olivia HowellsHannah Bartlett
May 26, 2011·Seminars in Ophthalmology·Margaret M DeangelisIvana K Kim
Aug 30, 2011·Investigative Ophthalmology & Visual Science·Günther WeigertLeopold Schmetterer

❮ Previous
Next ❯

Citations

Jan 24, 2015·Journal of Dietary Supplements·Catherine Ulbricht
Jan 16, 2015·Acta Ophthalmologica·Yuying JiFeng Wen
Oct 22, 2016·Current Eye Research·Joel KaluznyAmani A Fawzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal français d'ophtalmologie
M-B RougierJ-F Korobelnik
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Sibel DemirelEmin Ozmert
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Laura PatryasIan J Murray
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Raymond O Beirne
© 2022 Meta ULC. All rights reserved