PMID: 8592094Jan 1, 1996Paper

Short- or long-term effects of a low-protein diet on fibronectin and transforming growth factor-beta synthesis in Adriamycin-induced nephropathy

The Journal of Laboratory and Clinical Medicine
M NakayamaM Fujishima

Abstract

Increased synthesis and gene expression of fibronectin or transforming growth factor-beta (TGF-beta) have been reported to be involved in the progressive process of doxorubicin hydrochloride (Adriamycin)-induced nephropathy. In the present study, the effects of dietary protein restriction on the synthesis and gene expression of fibronectin or TGF-beta were investigated by immunoprecipitation, Northern blotting, and TGF-beta bioassay in this model after subjects were given either short- or long-term low-protein diets. In the long-term diet experiment, either a normal protein diet (NPD, 20%) or low-protein diet (LPD, 5%) was fed to the Adriamycin rats for 8 weeks after the injection of Adriamycin. An 8-week LPD significantly ameliorated kidney destruction and remarkably reduced the fibronectin synthesis. Furthermore, the significant decreases of the latent TGF-beta secretion and the expression of TGF-beta 1 mRNA were observed in the Adriamycin rats fed an 8-week LPD. In the short-term diet experiment, an NPD or LPD was fed to the Adriamycin rats for 2 weeks at weeks 4, 8, or 16 after the injection of Adriamycin. A 2-week LPD did not ameliorate kidney damage. Although fibronectin synthesis by the renal cortex in the Adriamycin rat...Continue Reading

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Citations

Jun 27, 2007·Nature Clinical Practice. Nephrology·Denis Fouque, Michel Aparicio
Jan 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lan HeYuhao Li
Apr 24, 2017·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni Fm Strippoli
Dec 27, 2011·Journal of Speech, Language, and Hearing Research : JSLHR·Derek J StilesRuth A Bentler
Mar 16, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Toshiyuki Nakao, Tomonari Okada
Jan 6, 2009·Seminars in Nephrology·Denis Fouque, Fitsum Guebre-Egziabher

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