Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus

The Cochrane Database of Systematic Reviews
A SiebenhoferT R Pieber

Abstract

Short acting insulin analogue use for diabetic patients is still controversial, as reflected in many scientific debates. To assess the effects of short acting insulin analogues versus regular human insulin. The Cochrane Library (Issue 3, 2005), MEDLINE, EMBASE until September 2005. Randomised controlled trials with an intervention duration of at least 4 weeks. Trial selection and evaluation of study quality was done independently by two reviewers. Altogether 8274 participants took part in 49 randomised controlled studies. Most studies were of poor methodological quality. In patients with type 1 diabetes, the weighted mean difference (WMD) of HbA1c was -0.1% (95% CI: -0.2 to -0.1) in favour of insulin analogue, whereas in patients with type 2 diabetes the WMD was 0.0% (95% CI: -0.1 to 0.0). In subgroup analyses of different types of interventions in type 1 diabetic patients, the WMD in HbA1c was -0.2% (95% CI: -0.3 to -0.1) in favour of insulin analogue in studies using continuous subcutaneous insulin injections (CSII), whereas for conventional intensified insulin therapy (IIT) studies the WMD in HbA1c was -0.1% (95% CI: -0.1 to 0.0). The WMD of the overall mean hypoglycaemic episodes per patient per month was -0.2 (95% CI: -1.1...Continue Reading

References

Jun 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·C Bradley, K S Lewis
Feb 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·E MosekildeB Thorsteinsson
Aug 10, 1989·The New England Journal of Medicine·B Zinman
Sep 1, 1987·Diabetes Care·D J CoxJ Butterfield
May 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·L Heinemann
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jan 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·S K GargH P Chase
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A PfütznerJ Beyer
Jul 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·L HeinemannT Heise
Apr 17, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·S SchmaussR Landgraf
Aug 1, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·T Rönnemaa, J Viikari
Apr 29, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·A ColombelB Charbonnel
Sep 10, 1999·Diabetes Care·L JovanovicE J Bastyr

❮ Previous
Next ❯

Citations

May 12, 2010·International Journal of Clinical Practice·P AschnerUNKNOWN Global Partnership for Effective Diabetes Management
Apr 12, 2013·Cardiovascular Diabetology·Diethelm TschöpePetra-Maria Schumm-Draeger
Feb 18, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sumeet R SinghHeather Bennett
Feb 18, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Andrea Siebenhofer-KroitzschJohannes Plank
May 9, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jeff Unger
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Satoru Yamada
Dec 5, 2012·ISRN Endocrinology·Edoardo Mannucci
Dec 5, 2015·Diabetologia·Hans Törnblom
Nov 3, 2016·Journal of Diabetes Science and Technology·Marie Moth HenriksenUlrik Pedersen-Bjergaard
Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Susan S Braithwaite
Jul 1, 2016·The Cochrane Database of Systematic Reviews·Birgit FullertonFerdinand M Gerlach
Feb 6, 2017·The Cochrane Database of Systematic Reviews·Sinéad M O'NeillPatricia M Kearney
Dec 18, 2018·The Cochrane Database of Systematic Reviews·Birgit FullertonFerdinand M Gerlach
Jul 20, 2007·Diabetologia·F Holleman, E A M Gale
Jan 6, 2009·Diabetes, Obesity & Metabolism·B SheldonJ Wright
Aug 28, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·C PratoomsootW J Valentine
Sep 17, 2009·Pediatric Diabetes·Hans-Jacob BangstadRagnar Hanas
Oct 8, 2014·Nature Reviews. Endocrinology·Brian M Frier
Dec 20, 2012·Wiener klinische Wochenschrift·Monika LechleitnerThomas C Wascher
Jan 10, 2013·Current Atherosclerosis Reports·Linde M MorsinkMichaela Diamant
Sep 10, 2013·Irish Journal of Medical Science·N L ZaharanK Bennett
Jan 25, 2014·Paediatric Drugs·Faisal S Malik, Craig E Taplin
May 24, 2014·Diabetes Care·George Grunberger
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·T C Skinner, F J Cameron
Nov 26, 2013·Diabetes, Obesity & Metabolism·H Thabit, R Hovorka
Jul 19, 2011·Self and Identity : the Journal of the International Society for Self and Identity·William G Shadel, Daniel Cervone
Jun 15, 2017·BMJ Open Diabetes Research & Care·Peter MoströmMarcus Lind
Aug 2, 2008·Diabetes, Obesity & Metabolism·E MannucciN Marchionni
Dec 12, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·E S KilpatrickS L Atkin
Jan 17, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·C WangI Idris
Apr 22, 2008·The Cochrane Database of Systematic Reviews·B RichterC L Lerch
Jun 9, 2016·The Cochrane Database of Systematic Reviews·Diane FarrarHelen M West
Jun 15, 2017·Ciência & saúde coletiva·Erick Soares Lisboa, Luis Eugenio Portela Fernandes de Souza
Dec 20, 2013·Journal of Diabetes Science and Technology·David KerrFrancisco Javier Ampudia-Blasco
Apr 14, 2015·Diabetes/metabolism Research and Reviews·Paolo PozzilliEric Renard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

© 2022 Meta ULC. All rights reserved