Short-acting nifedipine and diltiazem do not reduce the incidence of cardiac events in patients with healed myocardial infarction. Secondary Prevention Group

Circulation
K IshikawaR Katori

Abstract

The administration of calcium antagonists to patients with healed myocardial infarction is a controversial treatment. This study was conducted to elucidate the effect of short-acting nifedipine and diltiazem on cardiac events in patients with healed myocardial infarction. A controlled clinical open trial of 1115 patients with healed myocardial infarction was carried out between 1986 and 1994. The patients included 595 who received no calcium antagonist, 341 who received short-acting nifedipine 30 mg/d, and 179 who received short-acting diltiazem 90 mg/d. The primary end points were cardiac events, which were defined as fatal or nonfatal recurrent myocardial infarction; death from congestive heart failure; sudden death; and hospitalization because of worsening angina, congestive heart failure, or premature ventricular contractions. Cardiac events occurred in 51 patients (8.6%) in the no-calcium-antagonist group and 54 (10.4%) in the calcium-antagonist group (odds ratio, 1.24; 95% CI, 0.83 to 1.85), demonstrating that the calcium antagonists did not reduce the incidence of cardiac events. Subgroup analysis revealed no beneficial effects of these drugs for reducing cardiac events in patients with such complications as hypertension...Continue Reading

References

Feb 1, 1977·The American Journal of Cardiology·J S ForresterH J Swan
Feb 1, 1976·American Journal of Epidemiology·O Miettinen
Jun 11, 1992·Journal of the American College of Cardiology·S C WongE M Dwyer
Oct 1, 1990·The American Journal of Cardiology·F H Messerli
Nov 11, 1989·BMJ : British Medical Journal·P H HeldC D Furberg
Aug 18, 1988·The New England Journal of Medicine·UNKNOWN Multicenter Diltiazem Postinfarction Trial Research Group
Oct 1, 1967·The American Journal of Cardiology·T Killip, J T Kimball
Aug 23, 1995·JAMA : the Journal of the American Medical Association·B M PsatyP W Wahl

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Citations

Aug 26, 1998·Journal of the American College of Cardiology·K SakataC Kurata
Nov 5, 1999·The New England Journal of Medicine·D R Abernethy, J B Schwartz
Oct 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Kinji IshikawaUNKNOWN Secondary Prevention Group
Dec 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Kinji IshikawaUNKNOWN Secondary Prevention Group
Sep 6, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshihiko IshimitsuHiroaki Matsuoka
Mar 21, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·UNKNOWN Japanese Society of Hypertension
Jan 9, 2004·Japanese Heart Journal·Hiroki FurutaKinji Ishikawa
Sep 22, 2007·Journal of Hypertension·Yoshiki YuiUNKNOWN Japan Multicenter Investigation for Cardiovascular Diseases B (JMIC-B) Study Group
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eliot R BeaubienH Jay Biem
Jun 23, 2007·Annals of Emergency Medicine·Philip B DattiloCharles Nordin
May 26, 1999·Current Problems in Cardiology·M FreherM Gheorgiade
Apr 15, 2004·The American Journal of Cardiology·UNKNOWN Japanese beta-Blockers and Calcium Antagonists Myocardial Infarction (JBCMI) Investigators
Apr 26, 2014·Channels·Rong HuoDe-Li Dong
May 14, 1999·Journal of the American Geriatrics Society·M W GillmanS B Soumerai
Jan 27, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke SuetaSeiji Hokimoto
Oct 2, 2003·The Annals of Pharmacotherapy·Menno E van der ElstAnthonius de Boer
Aug 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Shigemasa TaniKatsuo Kanmatsuse
Oct 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Takaaki TaniwaKinji Ishikawa
Feb 19, 2002·Clinical and Experimental Hypertension : CHE·T IshimitsuH Matsuoka

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