PMID: 8582131Nov 1, 1995Paper

Short administration of metformin improves insulin sensitivity in android obese subjects with impaired glucose tolerance

Diabetic Medicine : a Journal of the British Diabetic Association
André J ScheenP J Lefebvre

Abstract

In a double-blind, randomized, cross-over study, the metabolic effects of a short treatment with metformin (2 x 850 mg day-1 for 2 days and 850 mg 1 h before evaluation) were compared to those of placebo in 15 obese subjects (BMI: 33.2 +/- 0.9 kg m-2), with abdominal distribution of adipose tissue and impaired glucose tolerance. An intravenous glucose tolerance test (0.3 g glucose kg-1) was performed after each period of treatment. Areas under the curve (AUC0-180 min) were calculated for plasma glucose, insulin, and C-peptide levels. Glucose tolerance was estimated by the coefficient of glucose assimilation (KG). Insulin sensitivity (SI) and glucose effectiveness (SG) indices were calculated using Bergman's minimal model. Insulin secretion rate (ISR) was determined by deconvolution of plasma C-peptide levels and insulin metabolic clearance rate (MCR) was estimated by dividing AUC 1SR by AUC insulin. Fasting plasma insulin levels were reduced after metformin (89.3 +/- 15.9 vs 112.4 +/- 24.3 pmol l-1; p = 0.04). AUC glucose, KG and SG were similar in both tests. However, AUC insulin was reduced (39.7 +/- 6.5 vs 51.8 +/- 10.4 nmol min l-1; p = 0.02), while SI (6.98 +/- 1.14 vs 4.61 +/- 0.42 10(-5) min-1 pmol-1 l; p = 0.03) and ins...Continue Reading

References

Oct 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·E L Toth, I James
Mar 1, 1992·European Journal of Clinical Investigation·S M HaffnerR N Bergman
Jun 1, 1992·Diabetes Care·C J Bailey
Apr 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, F A Gries
Feb 1, 1988·The Journal of Clinical Investigation·K S PolonskyE Van Cauter
Jul 1, 1994·Diabetes/metabolism Reviews·M J CastilloP J Lefèbvre
Jul 1, 1994·Diabetes/metabolism Reviews·A J ScheenP J Lefèbvre
Feb 1, 1993·Diabetes Care·M Moser, H Ross
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE

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Citations

Sep 1, 1995·Diabetes/metabolism Reviews·A J ScheenP J Lefèbvre
Sep 27, 2003·Diabetes Technology & Therapeutics·Jane E-B Reusch, Roger Gadsby
Nov 16, 2002·Lancet·André J Scheen
Oct 25, 2011·European Journal of Pharmacology·Elisavet MoutzouriMoses Elisaf
Feb 28, 2001·Diabetes, Obesity & Metabolism·M Kobayashi
Dec 22, 1999·Endocrine Reviews·G A Bray, F L Greenway
Jan 2, 2001·Endocrine Reviews·S MatthaeiH U Häring
Feb 15, 2008·Endocrine Research·Michael StumvollStephan Matthaei
Apr 5, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·S B WheatcroftM T Kearney

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