Short and long term effects of antipsychotic medication on smooth pursuit eye tracking in schizophrenia

Psychopharmacology
S B HuttonE M Joyce

Abstract

Smooth pursuit abnormalities have been observed in antipsychotic naive first-episode patients, suggesting that they are intrinsic to the illness. However, it is not clear whether these abnormalities are as severe as those observed in more chronic patients. In addition, although research suggests that there are no short-term effects of conventional antipsychotic medication, the effects of long-term antipsychotic medication on smooth pursuit eye movements are relatively unknown. To determine the short and long term effects of antipsychotic medication on the smooth pursuit performance of first-episode and chronic patients with schizophrenia. We compared the smooth pursuit performance of antipsychotic-treated and untreated first-episode and chronic schizophrenic patients with healthy controls using a comprehensive range of performance measures. This included velocity gain, the number, type and size of intrusive and corrective saccades, and the average time between the change in direction of the target and the change in direction of the eye movement, a measure of subjects' ability to predict target movement. Chronic schizophrenic patients had significantly reduced velocity gain, took longer to respond to the change in target directi...Continue Reading

Citations

May 11, 2005·Experimental Brain Research·L Elliot HongGunvant K Thaker
Apr 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·H Magnus HaraldssonHannes Petursson
May 29, 2012·European Archives of Psychiatry and Clinical Neuroscience·Andreas SprengerRebekka Lencer
Dec 12, 2013·Translational Psychiatry·A SchmechtigU Ettinger
Apr 1, 2014·European Archives of Psychiatry and Clinical Neuroscience·Rebekka LencerJohn A Sweeney
Jul 28, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Florence ThibautUNKNOWN WFSBP Task Force on Biological Markers
Oct 19, 2010·Journal of Psychiatric Research·Laura Frances MartinJason R Tregellas
Dec 4, 2009·Neuroscience and Biobehavioral Reviews·Elena I IvlevaCarol A Tamminga
Nov 26, 2008·Brain and Cognition·James L ReillyJohn A Sweeney
Oct 10, 2008·Brain and Cognition·Nikolaos Smyrnis
Jun 8, 2004·Acta Psychiatrica Scandinavica·M P M BoksR-J van den Bosch
Aug 5, 2014·Vision Research·Mark S BoldingPaul D Gamlin
Dec 30, 2008·Biological Psychiatry·Celia J A MorganEileen M Joyce
Nov 5, 2016·Psychiatry and Clinical Neurosciences·Kentaro MoritaRyota Hashimoto
Jul 9, 2008·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Bertine E LahuisChantal Kemner
Jun 29, 2021·Frontiers in Behavioral Neuroscience·Fotios AthanasopoulosNikolaos Smyrnis
Nov 30, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·TianHong ZhangJiJun Wang

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