Short and long term neuro-behavioral alterations in type 1 diabetes mellitus pediatric population

World Journal of Diabetes
Edna LitmanovitchMarianna Rachmiel

Abstract

Type 1 diabetes mellitus (T1DM) is one of the most prevalent chronic conditions affecting individuals under the age of 18 years, with increasing incidence worldwide, especially among very young age groups, younger than 5. There is still no cure for the disease, and therapeutic goals and guidelines are a challenge. Currently, despite T1DM intensive management and technological interventions in therapy, the majority of pediatric patients do not achieve glycemic control goals. This leads to a potential prognosis of long term diabetic complications, nephrological, cardiac, ophthalmological and neurological. Unfortunately, the neurological manifestations, including neurocognitive and behavioral complications, may present soon after disease onset, during childhood and adolescence. These manifestations may be prominent, but at times subtle, thus they are often not reported by patients or physicians as related to the diabetes. Furthermore, the metabolic mechanism for such manifestations has been inconsistent and difficult to interpret in practical clinical care, as reported in several reviews on the topic of brain and T1DM. However, new technological methods for brain assessment, as well as the introduction of continuous glucose monito...Continue Reading

Citations

Sep 10, 2016·Journal of Diabetes Research·Amy Hughes LansingSamuel J Casella
Aug 16, 2017·Journal of Health Psychology·Alda TronconeDario Iafusco
Feb 27, 2020·Antioxidants & Redox Signaling·Cristina Carvalho, Susana Cardoso
Oct 14, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N F ShimkinaE R Barantsevich
Sep 25, 2019·International Journal of Environmental Research and Public Health·Ewelina Czenczek-LewandowskaArtur Mazur
May 22, 2019·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·F GigantiM P Viggiano

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