Short-arm human centrifugation with 0.4g at eye and 0.75g at heart level provides similar cerebrovascular and cardiovascular responses to standing

European Journal of Applied Physiology
Nandu GoswamiA P Blaber

Abstract

Orthostatic intolerance continues to be a problem with astronauts upon return to Earth as a result of cerebral and cardiovascular adaptations to weightlessness. We tested the hypothesis that artificial gravity from a short-arm human centrifuge (SAHC) could provide cerebral and cardiovascular stimuli similar to upright posture and thereby serve as a suitable countermeasure. We compared cardiovascular and cerebrovascular responses before, during, and after exposure to hyper-G with that of standing in healthy young participants. The head was positioned such that the middle cerebral artery (MCA) was 0.46 m from the center of rotation. Two levels of hyper-G that provided 1g and 2g at foot level were investigated. Continuous blood pressure, heart rate, calf blood volume, MCA mean blood flow velocity (MFV) and end-tidal CO2 were measured. Blood pressure at the level of the MCA (BP-MCA) and MFV was reduced during stand and at 2g. The relationship between MFV and BP-MCA at 2g was different from supine and similar to standing, while 1g centrifugation was not different from supine. The cardiovascular system was also not different from supine at 1g but was similarly challenged in 2g compared to stand. Our data suggest that short-arm centri...Continue Reading

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Aug 17, 2005·Current Pharmaceutical Biotechnology·T Mano
Jan 16, 2010·Journal of Applied Physiology·B VerheydenA E Aubert
May 28, 2011·Stroke; a Journal of Cerebral Circulation·Andrew P BlaberMahmood S Kassam
Jun 1, 2011·European Journal of Applied Physiology·Michael B StengerSteven H Platts
Apr 12, 2012·American Journal of Physiology. Heart and Circulatory Physiology·K A ZujR L Hughson
Oct 18, 2012·European Journal of Applied Physiology·Nandu GoswamiHelmut G Hinghofer-Szalkay
Nov 8, 2012·European Journal of Applied Physiology·Andrew P BlaberNandu Goswami
Jan 12, 2013·Aviation, Space, and Environmental Medicine·Andrew P BlaberNandu Goswami
Feb 1, 2014·Aviation, Space, and Environmental Medicine·Li-Fan Zhang, Alan R Hargens

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Citations

Jun 21, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Matthieu KomorowskiAndrew W Kirkpatrick
Jul 20, 2016·Medicine·Kieran PatelNandu Goswami
Jul 26, 2019·Journal of Applied Physiology·Ana Diaz-ArtilesLaurence R Young
Aug 16, 2018·Frontiers in Physiology·Zeynep MasatliOliver S Opatz
Nov 30, 2018·Frontiers in Physiology·Ana Diaz-ArtilesLaurence R Young
Feb 8, 2019·European Journal of Applied Physiology·Olivier WhiteNandu Goswami

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