Short-axis epicardial volume change is a measure of cardiac left ventricular short-axis function, which is independent of myocardial wall thickness

American Journal of Physiology. Heart and Circulatory Physiology
Martin UganderHåkan Arheden

Abstract

Fractional shortening (FS) by echocardiography is considered to represent the short-axis contribution to the stroke volume (SV), also called short-axis function. However, FS is mathematically coupled to the amount of myocardium, since it rearranges during atrioventricular plane displacement (AVPD). The SV is the sum of the volumes generated by 1) reduction in outer volume of the heart, and 2) inner AVPD. The long-axis contribution to the SV is generated by AVPD, and thus the short-axis contribution is the remaining outer volume change of the heart, which should be unrelated to myocardial wall thickness. We hypothesized that both endocardial and midwall shortening indexed to SV are dependent on myocardial wall thickness, whereas epicardial volume change (EVC) indexed to SV is not. Twelve healthy volunteers (normals), 12 athletes, and 12 patients with dilated cardiomyopathy (ejection fraction < 30%) underwent cine cardiac magnetic resonance imaging. Left ventricular long-axis function was measured as the portion of the SV, in milliliters, generated by AVPD. EVC was defined as SV minus long-axis function. Endocardial and midwall shortening were measured in a midventricular short-axis slice. Endocardial shortening/SV and midwall sh...Continue Reading

References

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Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Marcus CarlssonHakan Arheden
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Citations

May 9, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alicia M Maceira, Raad H Mohiaddin
Mar 4, 2017·Scientific Reports·Elira MaksutiMartin Ugander
Jan 21, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Sigurdur StephensenMarcus Carlsson
Aug 21, 2020·Journal of Applied Physiology·Felicia SeemannEinar Heiberg

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