Short CDAI: development and validation of a shortened and simplified Crohn's disease activity index

Inflammatory Bowel Diseases
Kelvin ThiaWilliam J Sandborn

Abstract

The aim of this study was to develop a shortened Crohn's Disease Activity Index (CDAI). A short CDAI was developed retrospectively using patient-level data from four budesonide clinical trials to select variables from the full CDAI which best predicted health-related quality of life as measured by the Inflammatory Bowel Disease Questionnaire (IBDQ), using the multiple linear regression model. The validity, reliability, and responsiveness of the short CDAI compared to the original CDAI were determined using data from nine clinical trials of budesonide. The variables selected for the short CDAI were abdominal pain, diarrhea frequency, and general well-being. In all nine studies involving 1373 patients with active and inactive CD (5863 visits), the Pearson correlation coefficients between the short CDAI scores and the original CDAI scores at baseline (r = 0.899, P < 0.001), and the score differences (r = 0.963, P < 0.001) were excellent. The short CDAI accounted for 82.4% of the variance of the original CDAI. The intraclass correlation coefficient for the short CDAI was marginally better than that for the full CDAI, and both demonstrated good reliability (r = 0.600 versus r = 0.549). In patients with active CD who remitted during ...Continue Reading

Associated Clinical Trials

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Citations

Aug 13, 2013·Journal of Crohn's & Colitis·Millie D LongRobert S Sandler
Sep 27, 2012·Digestive Diseases and Sciences·Fu-Jun LiFang-Gen Lu
Mar 22, 2014·Expert Review of Gastroenterology & Hepatology·Gian Eugenio TontiniHelmut Neumann
Oct 29, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hans H HerfarthKim L Isaacs
Oct 21, 2015·Journal of Clinical Gastroenterology·Millie D LongRobert S Sandler
Apr 18, 2013·Alimentary Pharmacology & Therapeutics·W-C Chen, E M M Quigley
Nov 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael D KappelmanRobert S Sandler
Apr 6, 2016·The American Journal of Gastroenterology·Lawrence S GainesMichael D Kappelman
Jun 3, 2015·Digestive Diseases and Sciences·Mehdi TorkiMohammad Hassan Emami
Jul 21, 2015·Inflammatory Bowel Diseases·Maria Paula HenaoJames D Lewis
Jul 17, 2015·European Journal of Gastroenterology & Hepatology·Ibrahim K OnalMehmet Arhan
Jun 15, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletBeth Rycroft
Feb 28, 2015·Inflammatory Bowel Diseases·Patricia D JonesMillie D Long
May 10, 2016·The Journal of Pediatrics·Marina ArvanitisMichael D Kappelman
Sep 9, 2016·Journal of Crohn's & Colitis·Julián PanésSimon P Travis
Sep 21, 2016·Journal of Crohn's & Colitis·M SeversUNKNOWN COIN study group and the Dutch Initiative on Crohn and Colitis
Jul 13, 2017·Inflammatory Bowel Diseases·Mirjam SeversBas Oldenburg
Mar 30, 2018·Digestive Diseases and Sciences·Ann Marie KerlinRobert S Sandler
Sep 12, 2018·Inflammatory Bowel Diseases·Jason ReichFrancis A Farraye
Mar 9, 2019·The American Journal of Gastroenterology·Edward L BarnesRobert S Sandler
Feb 29, 2020·Inflammatory Bowel Diseases·Marina ArvanitisMichael D Kappelman
Jul 10, 2019·Inflammatory Bowel Diseases·Lawrence S GainesMichael D Kappelman
Oct 19, 2016·Journal of Clinical Gastroenterology·Yaron NivIrit Avni
Dec 28, 2018·Inflammatory Bowel Diseases·Edward L BarnesRobert S Sandler
Mar 9, 2017·Scandinavian Journal of Gastroenterology·Laura MartelliEdouard Louis
Mar 23, 2018·Digestive Diseases and Sciences·Swathi EluriMichael D Kappelman
Jul 5, 2018·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Samantha ConleyNancy S Redeker
Nov 13, 2018·Inflammatory Bowel Diseases·Zunirah AhmedMaged K Rizk
May 19, 2020·Crohn's & Colitis 360·Christina M BauerRobert S Sandler

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