PMID: 2107613Jan 1, 1990Paper

Short chain diol metabolism in human disease states

Trends in Biochemical Sciences
J P CasazzaR L Veech

Abstract

Recent clinical studies have shown the presence of two short chain diols, meso-2,3-butanediol and D/L-2,3-butanediol, and in most cases 1,2-propanediol in either serum or urine collected from humans in several apparently unrelated disease states: congenital propionic and methylmalonic acidemia, premature infants, and alcoholics both in the presence and absence of ethanol. In addition 1,2-propanediol has been shown in patients during prolonged starvation, and in patients with diabetic keto-acidosis. No common defect is known to exist in these metabolic states. Understanding how these compounds are produced in clinically well-defined diseases such as methyl malonic and propionic aciduria, however, may help explain how and why these compounds are produced in alcoholics.

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Citations

Jan 1, 1993·Journal of Applied Toxicology : JAT·M SainiM K Amma
Jun 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Nilsson, A W Jones
May 3, 2003·Biochimica Et Biophysica Acta·Miklós Péter Kalapos
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Dec 2, 1999·Medical Hypotheses·M P Kalapos
May 12, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Chunhui DengXiangmin Zhang
Mar 16, 2017·Journal of Breath Research·Veronika Ruzsányi, Miklós Péter Kalapos
Jul 30, 2015·The Journal of Biological Chemistry·Eleonora NapoliCecilia Giulivi

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