Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function.

Nature Metabolism
James FramptonE S Chambers

Abstract

A key metabolic activity of the gut microbiota is the fermentation of non-digestible carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end products. SCFAs are absorbed from the gut lumen and modulate host metabolic responses at different organ sites. Evidence suggests that these organ sites include skeletal muscle, the largest organ in humans, which plays a pivotal role in whole-body energy metabolism. In this Review, we evaluate the evidence indicating that SCFAs mediate metabolic cross-talk between the gut microbiota and skeletal muscle. We discuss the effects of three primary SCFAs (acetate, propionate and butyrate) on lipid, carbohydrate and protein metabolism in skeletal muscle, and we consider the potential mechanisms involved. Furthermore, we highlight the emerging roles of these gut-derived metabolites in skeletal muscle function and exercise capacity, present limitations in current knowledge and provide suggestions for future work.

References

Nov 1, 1990·The Journal of Clinical Investigation·F ZurloE Ravussin
Jan 1, 1988·Advances in Enzyme Regulation·R L Veech, W L Gitomer
Oct 1, 1967·Acta Physiologica Scandinavica·J BergströmB Saltin
Apr 1, 1983·Journal of Animal Science·S Imoto, S Namioka
Feb 1, 1982·Pflügers Archiv : European journal of physiology·R P SteffenF J Haddy
Nov 1, 1994·Diabetologia·M L Villanueva-PeñacarrilloI Valverde
May 1, 1997·The British Journal of Nutrition·H JørgensenB O Eggum
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Feb 13, 2001·Scandinavian Journal of Medicine & Science in Sports·C NakaoY Sato
Mar 20, 2001·International Journal of Sport Nutrition and Exercise Metabolism·K D Tipton, R R Wolfe
Oct 2, 2001·The Journal of Physiology·L J van LoonA J Wagenmakers
Jan 14, 2003·Annals of Medicine·H A Koistinen, J R Zierath
Apr 10, 2003·Biochemical and Biophysical Research Communications·Niclas E NilssonBjörn Olde
Jul 4, 2003·The Journal of Nutrition·James R Davie
May 1, 1962·The Journal of Clinical Investigation·F LUNDQUISTS MUNCK-PETERSEN
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Charles H LangThomas C Vary
Mar 16, 2005·The Journal of Biological Chemistry·Takayuki AkimotoZhen Yan
Jul 21, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R B Ceddia
Apr 25, 2006·Biochemical and Biophysical Research Communications·Shoji SakakibaraTakashi Kadowaki
Apr 4, 2007·Cell Metabolism·Shaohui Huang, Michael P Czech
May 15, 2007·The Journal of Biological Chemistry·David Kitz KrämerAnna Krook
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sibylle JägerBruce M Spiegelman
Dec 7, 2007·The Journal of Nutritional Biochemistry·Markus WaldeckerDieter Schrenk
May 28, 2009·Journal of Agricultural and Food Chemistry·Tomoo KondoTakayuki Kaga
Jun 16, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Johanne G BloemenCornelis H Dejong
Oct 2, 2009·Clinical and Experimental Pharmacology & Physiology·Sean L McGee, Mark Hargreaves
Feb 19, 2010·The American Journal of Clinical Nutrition·William J Evans
Oct 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mikael BjursellMohammad Bohlooly-Y
Feb 4, 2011·The American Journal of Clinical Nutrition·Pablo J Fernandez-Marcos, Johan Auwerx
Mar 2, 2011·Molecular and Cellular Biochemistry·Mahmoud L Soliman, Thad A Rosenberger
Mar 23, 2011·Regulatory Peptides·María L Villanueva-PeñacarrilloNieves González
Sep 1, 2011·Diabetes Research and Clinical Practice·George DimitriadisSotirios A Raptis
Sep 6, 2011·Nature Cell Biology·Maria M Mihaylova, Reuben J Shaw

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Citations

Sep 2, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Shinjini BhattacharyaSucharita Sambashivaiah
Nov 19, 2020·International Journal of Molecular Sciences·Elisabeth WyartPaolo E Porporato
Nov 14, 2020·Environmental Microbiology·Jonathon A BriggsHarry Brumer
Jan 7, 2021·Nutrition and Metabolic Insights·Florence GizardFilipe De Vadder
Mar 7, 2021·Nutrients·Matthew D WatsonGregory J Grosicki
Mar 17, 2021·Critical Reviews in Food Science and Nutrition·Jie CaiYing Liang
Mar 27, 2021·Frontiers in Endocrinology·Lucas MassierRima M Chakaroun
Apr 24, 2021·Gut Microbes·Tomasz WilmanskiNathan D Price
Apr 22, 2021·International Journal of General Medicine·Jiaxi ZhaoXiaofeng Yu
Apr 1, 2021·AIDS Research and Human Retroviruses·Stephanie M DillonKristine M Erlandson
Jun 11, 2021·Frontiers in Physiology·Diliana Pérez-ReytorKatherine García
Jun 18, 2021·The Journal of Experimental Biology·Alinne P CastroJeeser A Almeida
May 23, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Sarah K KirschnerMariëlle P K J Engelen
Jul 6, 2021·Frontiers in Endocrinology·Manuel A González HernándezJohan W E Jocken
Jul 14, 2021·International Journal of Sports Medicine·Tindaro BongiovanniLiam Heaney
Jul 16, 2021·The American Journal of Chinese Medicine·Ya-Xin ZhangFeng-Hua Zhou
Jun 29, 2021·American Journal of Physiology. Endocrinology and Metabolism·Juulia H LautaojaJuha J Hulmi
Jun 18, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Sarah K KirschnerMariëlle P K J Engelen
Aug 17, 2021·Frontiers in Immunology·Derek TobinPhilip C Calder
Dec 3, 2020·Journal of Agricultural and Food Chemistry·Zhen-Dong YaoGang Zhao
Aug 28, 2021·International Journal of Molecular Sciences·Francesca LatinoFrancesco Fischetti
Sep 16, 2021·Journal of Cachexia, Sarcopenia and Muscle·Chaoran LiuRonald Man Yeung Wong
Sep 30, 2021·Journal of Cachexia, Sarcopenia and Muscle·James FramptonEdward S Chambers
Oct 2, 2021·Nature Reviews. Gastroenterology & Hepatology·Tiffany ToniVictoria Gershuni
Oct 5, 2021·American Journal of Physiology. Endocrinology and Metabolism·Sarah K KirschnerNicolaas E P Deutz

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Methods Mentioned

BETA
acetylation

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