PMID: 18716174Aug 22, 2008Paper

Short-chain fructooligosaccharides influence insulin sensitivity and gene expression of fat tissue in obese dogs

The Journal of Nutrition
Frédérique RespondekMarianne Diez

Abstract

Dietary fibers may modulate insulin resistance and glucose homeostasis in dogs. Their efficacy is, however, dependent on their origin, physical properties, and fermentability in the large bowel. Eight healthy Beagle dogs were fed a commercial diet at twice their maintenance requirements until they became obese. They were then maintained in the obese state and used in a cross-over design study to evaluate the effects of short-chain fructooligosaccharide (scFOS) supplementation (1% wt:wt dry matter in the diet). The euglycemic hyperinsulinemic clamp technique was performed before and after fattening and at the end of each 6-wk cross-over period. Fat tissue biopsies were taken in food-deprived and postprandial phases to measure mRNA abundance of genes involved with fatty acid, glucose metabolism, or inflammation. Insulin resistance appeared progressively with fattening and the rate of glucose infusion during euglycemic clamp was lower (P < 0.05) at the end of the fattening period (7.39 mg.kg(-1).min(-1)) than at baseline (21.21 mg.kg(-1).min(-1)). In stable obese dogs, scFOS increased (P < 0.05) the rate of glucose infusion compared with control (7.77 vs. 4.72 mg.kg(-1).min(-1)). Plasma insulin and triglyceride concentrations were...Continue Reading

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Citations

Oct 26, 2011·The British Journal of Nutrition·Márcio Antonio BrunettoAulus Cavalieri Carciofi
Apr 1, 2014·FEBS Letters·Calum J WalshPaul D Cotter
Mar 29, 2018·Applied Microbiology and Biotechnology·Muhammad Shahid Riaz RajokaJunling Shi
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Feb 9, 2018·Nutrition & Metabolism·Cindy Le BourgotFrédérique Respondek
Nov 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yang LyuMyriam Hesta

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