Short closure time values in PFA-100® are related to venous thrombotic risk. Results from the RETROVE Study

Thrombosis Research
Miquel Vázquez-SantiagoJuan Carlos Souto

Abstract

Platelets play a role in the pathophysiology of venous thromboembolism (VTE). Some studies have not found an association between VTE and platelet aggregation. The PFA-100® analyser is an in vitro assay for assessing primary haemostasis. But, there are no studies to evaluate its association with VTE. We investigated the contribution of the global platelet function and aggregation in the development of VTE. We analysed 800 individuals who were included in the RETROVE Study (Riesgo de Enfermedad TROmboembólica VEnosa). Global platelet function was evaluated as closure times (CT) with the agonists ADP and epinephrine using a PFA-100® analyser. Platelet aggregation was evaluated by Multiplate™ analyser. The VTE risk for all the parameters was calculated by unconditional logistic regression analyses considering the potential confounders: age, gender, body mass index (BMI), factor VIII (FVIII), the von Willebrand factor (vWF) and the ABO blood group system. The unadjusted odds ratio (OR) values ≤10th percentile for the PFAadp and PFAepi were 4.02 (95% CI, 2.76-5.95) and 3.33 (2.27-4.97). Also, after adjusting for vWF, we obtained lower OR for the PFAadp and for PFAepi: 2.24 (1.44-3.49) and 1.63 (1.04-2.59). But, the whole blood aggreg...Continue Reading

Citations

Jan 9, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria-Teresa Calderon-LopezArturo Matilla-Garcia
Dec 19, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Dolors LlobetJuan Carlos Souto

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