Short communication: a technique for delivering carbogen with high dose rate intraluminal brachytherapy in carcinoma of the oesophagus; early results and toxicity

The British Journal of Radiology
P J HoskinM I Saunders

Abstract

A technique to deliver carbogen with high dose rate afterloading therapy to the oesophagus is described. Treatment is given using a standard high dose rate (HDR) afterloading catheter which is passed through the tumour-bearing area of the oesophagus within a nasogastric tube. In order to achieve a gas-tight seal, a standard "oxygen" mask used for delivery of carbogen is modified to incorporate the nasogastric tube allowing the treatment catheter to pass through the mask and be connected to the afterloading machine. The technique has proven to be feasible and well tolerated during treatment in four patients treated in this way. Severe acute radiation toxicity, possibly attributable to the carbogen, has been encountered in these patients receiving 1500 cGy at 1 cm via the HDR catheter after 4050 cGy in 27 fractions in 9 days using CHART external beam. Modifications to the radiation scheduling is recommended to enable carbogen to be incorporated in this way.

References

Jan 1, 1992·The British Journal of Radiology·S DischeB D Michael
Mar 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A RojasK Reghebi
Oct 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DischeE Lartigau
Oct 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S W GollinsR Stout
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·A E BrewsterP A Burt

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