Short communication: antiretroviral therapy resistance mutations present in the HIV type 1 subtype C pol and env regions from therapy-naive patients in Zambia.

AIDS Research and Human Retroviruses
Sandra GonzalezCharles Wood

Abstract

The prevalence of antiretroviral therapy (ART) resistance mutations present in HIV-1 subtype C pol and env regions of the proviral DNA was analyzed and compared from therapy-naive individuals before (Cohort A) and after (Cohort B) the availability of free ART in Zambia. Mutations present in sequences published in a previous study from Zambian ART-naive individuals infected with subtype C were analyzed using current parameters for the classification of ART drug resistance and compared with Cohorts A and B. No statistically significant differences were observed when comparing mutations present in the pol and env of these cohorts. However, an increase in the number of minor, borderline, or partial resistance mutations as well as the presence of major resistance mutations were observed in Cohort B. These results suggest there is an increasing trend of drug resistance-associated mutations that could be a result of the availability of free ART in Zambia. Moreover, the high prevalence of resistance mutations observed for maraviroc and vicriviroc in both cohorts may suggest a limited efficacy of entry inhibitors on HIV-1 subtype C.

References

Feb 17, 1997·The Journal of Experimental Medicine·R I ConnorN R Landau
Jul 6, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·R L Edgeworth, K E Ugen
May 1, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ellen R CooperUNKNOWN Women and Infants' Transmission Study Group
Aug 4, 2005·Bioinformatics·Tulio de OliveiraAnne-Mieke Vandamme
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Jeffrey S A StringerMoses Sinkala
Aug 22, 2006·The Journal of Infectious Diseases·David Katzenstein
May 30, 2008·AIDS Research and Human Retroviruses·Luis E Soto-RamirezUNKNOWN NISDI Perinatal Study Group
Nov 4, 2008·Current Opinion in Infectious Diseases·Andrew J Buckton
Feb 13, 2009·The Journal of Infectious Diseases·Birgitte B SimenUNKNOWN Terry Beirn Community Programs for Clinical Research on AIDS
Mar 3, 2009·Journal of Clinical Pharmacy and Therapeutics·H DhamiS Nagar

❮ Previous
Next ❯

Citations

Mar 19, 2014·Critical Reviews in Microbiology·George Panos, Dionysios Christos Watson
Feb 8, 2013·Viruses·Leonardo Augusto Luvison Araújo, Sabrina E M Almeida
Jul 3, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hongyan GuoXiaohong Kong
Feb 18, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Leonardo Augusto Luvison AraújoSabrina Esteves de Matos Almeida
Nov 6, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Soham GuptaAnita Shet
Feb 24, 2018·Journal of the International Association of Providers of AIDS Care·Sanjay PujariDigamber Dabhade

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
genotyping

Software Mentioned

SPSS
HIV Bioinformatics Bioafrica
REGA
BioEdit

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.