Short communication: Circulating fatty acylcarnitines are elevated in overweight periparturient dairy cows in association with sphingolipid biomarkers of insulin resistance

Journal of Dairy Science
J E RicoJ W McFadden

Abstract

Defects in mitochondrial fatty acid processing are associated with the development of fatty liver disease, inflammation, and insulin resistance in overweight nonruminants. Surplus fatty acids (FA) and defects in FA oxidation favor the accumulation of fatty acylcarnitines (FAC) and the sphingolipid ceramide. Moreover, elevated circulating FAC and ceramide concentrations are inversely related to insulin action. Because we have previously demonstrated that plasma ceramide levels increase during the transition from gestation to lactation, our aim was to determine whether changes in plasma medium- and long-chain FAC levels are related to circulating FA and sphingolipids in peripartal dairy cows. We hypothesized that plasma FAC levels would be higher in overweight cows experiencing increased lipolysis, and that FAC levels would be positively associated with elevations in plasma ceramides. Twenty-one multiparous Holstein cows were grouped according to body condition score (BCS) at d -30 prepartum as lean (BCS <3.0; n = 10) or overweight (BCS >4.0; n = 11). Blood was collected at d -30, -15, -7, and 4, relative to parturition. Circulating FAC and ceramide levels were determined using liquid chromatography and tandem mass spectrometry. ...Continue Reading

References

Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Agnieszka Dobrzyń, Jan Górski
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Feb 3, 2004·Annals of Neurology·Norman J HaugheyMark P Mattson
Feb 6, 2004·Journal of Dairy Science·J L Edwards, P R Tozer
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy
Oct 9, 2004·The Veterinary Clinics of North America. Food Animal Practice·Ric R GrummerA Hayirli
Jul 23, 2005·International Journal of Clinical Practice. Supplement·R A DeFronzo
Feb 1, 2006·Progress in Lipid Research·Scott A Summers
Apr 29, 2010·Metabolism: Clinical and Experimental·Satish C KalhanMike Milburn
Aug 19, 2010·The Journal of Veterinary Medical Science·Chuang XuCheng Xia
Mar 24, 2011·Journal of Dairy Science·N B LitherlandJ K Drackley
Aug 9, 2011·Metabolism: Clinical and Experimental·Maria A Ramos-RomanElizabeth J Parks
Dec 22, 2012·Diabetes·Marieke G SchoonemanMaarten R Soeters
May 15, 2013·Cell Metabolism·William L HollandPhilipp E Scherer
Jul 3, 2013·The Veterinary Clinics of North America. Food Animal Practice·Lorraine M Sordillo, William Raphael
Mar 19, 2014·Journal of Dairy Science·D HailemariamB N Ametaj
Apr 29, 2014·Biochimica Et Biophysica Acta·Georgios GrammatikosJosef Pfeilschifter
Jun 4, 2014·BMC Veterinary Research·Sandro ImhaslyChristian Gerspach
Oct 25, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Céline AguerMary-Ellen Harper
Dec 3, 2014·Cell Metabolism·Timothy Hla, Richard Kolesnick

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Citations

Oct 4, 2018·The Journal of Nutrition·J Eduardo RicoJoseph W McFadden
Jul 16, 2019·Journal of Dairy Science·J W McFadden, J E Rico
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·J W McFadden
Jun 6, 2020·Animal : an International Journal of Animal Bioscience·E F EckelB N Ametaj
Aug 5, 2020·Journal of Dairy Science·Morteza H GhaffariHelga Sauerwein
Mar 6, 2021·Journal of Animal Science and Biotechnology·Madison N MyersG Andres Contreras

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