Short Communication: Discordance in Drug Resistance Mutations Between Blood Plasma and Semen or Rectal Secretions Among Newly Diagnosed HIV-1-Infected Thai Men Who Have Sex with Men

AIDS Research and Human Retroviruses
Akarin HiransuthikulNittaya Phanuphak

Abstract

Human immunodeficiency virus 1 (HIV-1) infection is most commonly transmitted by sexual contact across mucosal surfaces. Information on concordance in drug resistance profile between blood plasma and anogenital compartments in resource-limited settings is limited. We aimed to determine discordances in genotypic drug resistance-associated mutations (DRAMs) between blood plasma and semen or rectal secretions among newly diagnosed, antiretroviral therapy (ART)-naive, HIV-1-infected Thai men who have sex with men (MSM). Blood plasma, semen, and rectal secretions of HIV-1-infected Thai MSM enrolled from the Test and Treat cohort were tested for genotypic mutations in the reverse transcriptase and protease genes. Seven participants with baseline DRAMs in blood plasma were included in this analysis. In anogenital samples, HIV-1 RNA could be fully amplified for DRAMs assessment in semen from three participants and in rectal secretions from four participants. DRAMs were identified in semen from two of three participants and in rectal secretions from four of four participants. Three participants had DRAMs in anogenital compartments that were not detected in blood plasma-one had DRAMs in semen that was not detected in blood plasma (I54FI)...Continue Reading

References

Jan 10, 2003·Nucleic Acids Research·Soo-Yon RheeRobert W Shafer
Mar 12, 2003·Journal of Medical Virology·Laura MonnoGioacchino Angarano
Jun 1, 2010·Journal of Medical Virology·T L KatzensteinL B Jørgensen
Nov 3, 2016·Journal of the International AIDS Society·Donn J ColbyUNKNOWN Search 010/RV 254 Study Group

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Methods Mentioned

BETA
genotyping
biopsy

Software Mentioned

Stata

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