Short communication: HIV type 1 genetic diversity among tea plantation workers in Kericho, Kenya

AIDS Research and Human Retroviruses
Miguel A ArroyoFrancine E McCutchan

Abstract

In preparation for HIV-1 vaccine trials in Kenya, 2801 study volunteers, from a tea plantation in Kericho, were recruited as part of a prospective vaccine cohort development study. Cryopreserved plasma was available from 401 HIV-positive volunteers, and was the source of viral RNA for genotyping by the multiregion hybridization assay (MHA). Logistic regression was performed to determine association of risk factors and HIV-1 recombinant and dual infections. At baseline, HIV-1 subtype A was the dominant circulating pure subtype (56%), followed by subtype D (10%) and C (5%). Recombinant HIV-1 strains accounted for almost one-third of all infections (29%), with 7% infected with a dual strain of the HIV-1 variants described. A higher number of HIV-1 recombinant and dual infections was observed among volunteers who were 18-24 and 25-29 years of age, affiliated with the Luo tribe, had been married two or more times, reported not being circumcised, and had STI symptoms in the past 6 months. Adjusted odds ratios (AOR) significantly associated with HIV-1 recombinant and dual infection were age difference from current spouse (5-9 years; AOR = 2.5, 95% CI = 1.2-5.3 and > or = 10 years; AOR = 3.1, 95% CI = 1.5-6.4) and reported STI symptoms...Continue Reading

References

Jul 31, 2003·Journal of Biosocial Science·Priscilla A AkwaraAndrew Hinde
Apr 13, 2004·AIDS·Guowei FangHarold Burger
Aug 24, 2004·AIDS Research and Human Retroviruses·Miguel A ArroyoFrancine E McCutchan
Oct 18, 2005·AIDS Research and Human Retroviruses·Megan C SteainNitin K Saksena
Jul 13, 2006·AIDS Research and Human Retroviruses·Karl-Heinz HerbingerMichael Hoelscher
Sep 19, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Miguel A ArroyoFrancine E McCutchan
Jun 30, 2007·Epidemiology and Infection·G FogliaD L Birx

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Methods Mentioned

BETA
PCR
genotyping
circumcision

Software Mentioned

JMP

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