Short Communication: Is Ethanol-Based Hand Sanitizer Involved in Acute Pancreatitis after Excessive Disinfection?-An Evaluation with the Use of PBPK Model.

Journal of Toxicology
Céline Huynh-DelermeCatherine Desmares

Abstract

An occupational physician reported to the French Health Products Safety Agency (Afssaps) a case of adverse effect of acute pancreatitis (AP) in a teaching nurse, after multiple demonstrations with ethanol-based hand sanitizers (EBHSs) used in a classroom with defective mechanical ventilation. It was suggested by the occupational physician that the exposure to ethanol may have produced a significant blood ethanol concentration and subsequently the AP. In order to verify if the confinement situation due to defective mechanical ventilation could increase the systemic exposure to ethanol via inhalation route, a physiologically based pharmacokinetic (PBPK) modeling was used to predict ethanol blood levels. Under the worst case scenario, the simulation by PBPK modeling showed that the maximum blood ethanol concentration which can be predicted of 5.9 mg/l is of the same order of magnitude to endogenous ethanol concentration (mean = 1.1 mg/L; median = 0.4 mg/L; range = 0-35 mg/L) in nondrinker humans (Al-Awadhi et al., 2004). The present study does not support the likelihood that EBHS leads to an increase in systemic ethanol concentration high enough to provoke an acute pancreatitis.

References

Mar 1, 1986·Journal - Forensic Science Society·L Campbell, H K Wilson
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Mar 27, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R U PendlingtonD Howes
Jul 24, 2004·Science & Justice : Journal of the Forensic Science Society·A Al-AwadhiZ Al-Hatali
Nov 14, 2006·The American Journal of Emergency Medicine·Michael A MillerChad S Crystal
Jan 15, 2008·Lancet·Jean-Louis FrossardCatherine M Pastor
Oct 24, 2008·American Journal of Infection Control·Sohvi KinnulaMatti Uhari

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Citations

Jul 28, 2015·Regulatory Toxicology and Pharmacology : RTP·Andrew MaierAntonio Quiñones-Rivera

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Software Mentioned

AIHA
American Hygiene Association ( AIHA )
ACSLX

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