Short Communication: Low Expression of Activation and Inhibitory Molecules on NK Cells and CD4(+) T Cells Is Associated with Viral Control

AIDS Research and Human Retroviruses
Natalia A TabordaKeith R Fowke

Abstract

Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4(+) T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF-α and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.

References

Dec 14, 2004·The Journal of Infectious Diseases·Judie B AlimontiKeith R Fowke
Mar 23, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P A VelillaM T Rugeles
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fransje A KoningHanneke Schuitemaker
Apr 21, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Carlos Julio MontoyaMaria Teresa Rugeles
Aug 17, 2006·AIDS Research and Human Retroviruses·Philip J NorrisMichael P Busch
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Nov 11, 2008·Current HIV Research·Wildeman ZapataMaria T Rugeles
Dec 10, 2008·Expert Opinion on Biological Therapy·B M BakerB D Walker
Aug 7, 2009·The Journal of Infectious Diseases·Florencia PereyraBruce D Walker
May 11, 2010·European Journal of Immunology·Karlhans F CheMarie Larsson
Dec 17, 2010·Journal of Virology·LaTonya D WilliamsPaul A Goepfert
Dec 29, 2010·Current HIV/AIDS Reports·Alka Khaitan, Derya Unutmaz
Mar 16, 2011·The Journal of Clinical Investigation·Huabiao ChenMathias Lichterfeld
Jan 14, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Natalia A TabordaCarlos J Montoya
Jan 8, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Zhu LiZhengwen Liu
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Francesco MarrasAndrea De Maria
Oct 9, 2013·AIDS Research and Human Retroviruses·Wildeman ZapataMaría T Rugeles
Nov 22, 2013·Retrovirology·Catherine M CardKeith R Fowke
Jan 15, 2014·The Journal of Infectious Diseases·Julie LajoieKeith R Fowke

❮ Previous
Next ❯

Citations

Jan 12, 2016·AIDS Research and Human Retroviruses·Martin PlattenClara Lehmann
Oct 13, 2017·International Journal of Molecular Sciences·Asma Beldi-Ferchiou, Sophie Caillat-Zucman
Jun 24, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Filippos PorichisDaniel E Kaufmann
Jul 29, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Nicholas PomplunEva G Rakasz
Dec 12, 2019·Journal of Medical Virology·Marília M Loureiro Dos ReisEnrique R Argañaraz
Apr 6, 2017·Frontiers in Immunology·Fabio E LealLishomwa C Ndhlovu
Jan 18, 2019·PLoS Pathogens·Colin G GraydonKeith R Fowke
Sep 17, 2020·Nature Reviews. Clinical Oncology·Jacob A Myers, Jeffrey S Miller
Mar 3, 2020·Frontiers in Immunology·Muhammad KhanHua Wang
Sep 3, 2019·Frontiers in Immunology·Olivier LucarStephanie Jost
Nov 6, 2018·Frontiers in Immunology·Lizdany Flórez-ÁlvarezWildeman Zapata

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow cytometry

Software Mentioned

- Pad
Bioplex Manager
FlowJo
Graph

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis