Short communication: Ovine leukocyte telomere length is associated with variation in the cortisol response to systemic bacterial endotoxin challenge

Journal of Dairy Science
L YipNiel A Karrow

Abstract

Stress has been associated with biological aging and numerous age-related diseases. This may be due, in part, to accelerated shortening of telomeres, which are critical genomic structures that cap and protect chromosomal ends. Dysfunction of the hypothalamic-pituitary-adrenal axis may indirectly contribute to telomere shortening if an animal reacts too strongly or weakly to a stressor, leading to accelerated biological aging. In this study, outbred Rideau-Arcott sheep were stress challenged with Escherichia coli endotoxin and classified as high, middle, or low cortisol responders to investigate a potential relationship between cortisol response and age, and telomere length. In the present study, no association was found between age and telomere length. The study, however, revealed shorter telomeres in high and low cortisol responders compared with the middle cortisol responders, which suggests that health and longevity may be compromised in extreme high- and low-stress-responding sheep.

References

Jun 20, 1992·Journal of Molecular Biology·M Z LevyC B Harley
Jun 1, 1989·Biology of Reproduction·V H ParraguezM Serón-Ferré
Jun 9, 1999·Nature·P G ShielsA E Schnieke
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Aug 9, 2003·Nucleic Acids Research·R G Rutledge, C Côté
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Elissa S EpelRichard M Cawthon
Jun 30, 2006·Veterinary Immunology and Immunopathology·Leah C KabaroffNiel A Karrow
Apr 25, 2007·Molecular Reproduction and Development·Basil AlexanderW Allan King
Mar 5, 2011·Experimental Dermatology·Erin M Buckingham, Aloysius J Klingelhutz
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·J A StrykerN A Karrow
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·T PritchardE Wall
Nov 1, 2012·Science Signaling·Sonja EntringerPathik D Wadhwa
Jan 11, 2013·Epidemiologic Reviews·Jason L Sanders, Anne B Newman
Jan 22, 2013·Ageing Research Reviews·Aysel MüezzinlerHermann Brenner
Mar 16, 2013·Psychoneuroendocrinology·Kirstin AschbacherElissa Epel
Dec 20, 2013·The Journal of Experimental Biology·Julian A T Dow
Jan 30, 2014·Longevity & Healthspan·Clara Correia-MeloJoão F Passos
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elissa S Epel, Gordon J Lithgow
May 20, 2015·Human Genetics·Jennifer H BarrettKaren A Pooley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

© 2021 Meta ULC. All rights reserved