Short Communication: Persistence of HIV Antibody Avidity in the Presence of Antiretroviral Therapy

AIDS Research and Human Retroviruses
Kelly A CurtisMichele Owen

Abstract

The effects of antiretroviral therapy (ART) on the performance of HIV incidence assays have been well documented. To improve upon current assay approaches or focus the development of future assays, studies are needed to characterize the effects of ART on all candidate HIV incidence assays. In this study, we compared the performance of three antibody avidity-based HIV incidence assays, the Limiting Antigen (LAg), Bio-Rad Avidity, and HIV-1 Multiplex assays, using a well-defined cohort of recent HIV-1 seroconverters composed of ART-naive HIV-1-infected individuals and those who received ART early or delayed in the course of infection. Differences in the performance of all three avidity-based incidence assays were noted with study subjects who received ART. The LAg assay and Multiplex total antibody measurements (nMFI) exhibited similar kinetics in reactivity, as these assays tended to fluctuate with changes in viral load. In the early ART group, all seven subjects remained recent by both assays at time points >1 year postseroconversion, and assay values declined dramatically postdelayed ART initiation. In contrast, the two-well, antibody-dissociation avidity assays, Bio-Rad Avidity and Multiplex avidity index (AI) measurements, c...Continue Reading

References

Jul 11, 1998·JAMA : the Journal of the American Medical Association·R S JanssenM P Busch
Mar 18, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Barbara SuligoiGiovanni Rezza
Jul 5, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bhupat D RawalMichael P Busch
May 19, 2011·AIDS Research and Human Retroviruses·Kelly A CurtisS Michele Owen
Jul 7, 2011·PLoS Medicine·UNKNOWN Incidence Assay Critical Path Working Group

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Citations

Jan 25, 2020·Sexually Transmitted Diseases·Silvina MasciotraS Michele Owen
Jun 21, 2019·Journal of Clinical Microbiology·Mark M ManakUNKNOWN RV254/SEARCH010 and the RV217 Study Teams
Jun 20, 2020·PloS One·Oluwasanmi AdedokunKwasi Torpey
Sep 6, 2017·Journal of the International AIDS Society·Tendesayi KufaAdrian Puren

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