Short communication: Uncovering quantitative trait loci associated with resistance to Mycobacterium avium ssp. paratuberculosis infection in Holstein cattle using a high-density single nucleotide polymorphism panel

Journal of Dairy Science
Sanjay MallikarjunappaSameer D Pant

Abstract

Mycobacterium avium ssp. paratuberculosis (MAP) is the etiological agent of Johne's disease in cattle. Johne's disease is a disease of significant economic, animal welfare, and public health concern around the globe. Therefore, understanding the genetic architecture of resistance to MAP infection has great relevance to advance genetic selection methods to breed more resistant animals. The objectives of this study were to perform a genome-wide association study of previously analyzed 50K genotypes now imputed to a high-density single nucleotide polymorphism panel (777K), aiming to validate previously reported associations and potentially identify additional single nucleotide polymorphisms associated with antibody response to MAP infection. A principal component regression-based genome-wide association study revealed 15 putative quantitative trait loci (QTL) associated with the MAP infection phenotype (serum or milk ELISA tests) on 9 different chromosomes (Bos taurus autosomes 5, 6, 7, 10, 14, 15, 16, 20, and 21). These results validated previous findings and identified new QTL on Bos taurus autosomes 15, 16, 20, and 21. The positional candidate genes NLRP3, IFi47, TRIM41, TNFRSF18, and TNFRSF4 lying within these QTL were identif...Continue Reading

References

Jul 1, 1996·The Veterinary Clinics of North America. Food Animal Practice·R W Sweeney
Jul 29, 1999·Preventive Veterinary Medicine·S L OttB A Wagner
Dec 3, 2003·Trends in Immunology·Stephen E GirardinPhilippe J Sansonetti
Mar 26, 2004·Nature Reviews. Immunology·Gregory A TaylorAlan Sher
Apr 12, 2006·Journal of Dairy Science·M G GondaB W Kirkpatrick
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Dec 23, 2008·Nature Genetics·Alexandra-Chloé VillaniDenis Franchimont
Jun 3, 2010·Nature Reviews. Genetics·Jonathan Marchini, Bryan Howie
Mar 11, 2011·Trends in Immunology·Md Hasan ZakiThirumala-Devi Kanneganti
Oct 26, 2011·The Veterinary Clinics of North America. Food Animal Practice·Brian W Kirkpatrick, George E Shook
Jun 18, 2014·BMC Genomics·Mehdi SargolzaeiFlavio S Schenkel
Nov 5, 2016·PloS One·Raphaële ThiébautVincent Ollendorff
Mar 3, 2017·The Journal of Dairy Research·Ahmed M SallamBrian W Kirkpatrick
Sep 3, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Marcello Del CorvoGiulietta Minozzi

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Citations

Sep 6, 2020·Genetics, Selection, Evolution : GSE·Seyed Mohammad GhoreishifarArash Javanmard

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