PMID: 7545705Oct 1, 1995Paper

Short-contact anthralin treatment augments therapeutic efficacy of cyclosporine in psoriasis: a clinical and pathologic study

Journal of the American Academy of Dermatology
S L GottliebJ G Krueger

Abstract

Psoriasis is characterized by immune activation and increased epidermal proliferation. Cyclosporine acts by reducing T lymphocyte numbers and lymphokine production. Anthralin inhibits keratinocyte proliferation. We investigated whether topical anthralin would augment clearing of psoriasis produced by systemic cyclosporine. Twelve patients with psoriasis were treated with cyclosporine (5 mg/kg per day). Patients applied anthralin only to plaques on half of their body. They were treated until a remission or maximum benefit was achieved. Disease activity was assessed by a severity index and quantitative histopathologic markers. Of the 12 patients, the skin of five cleared within 10 weeks irrespective of anthralin use. The other seven (slow responders) continued treatment for a mean of 18 weeks. Slow responders had a significantly lower severity index, a thinner epidermis, fewer CD8+ cells, and fewer proliferating keratinocytes on the anthralin-treated side than on the non-anthralin-treated side. The combination of cyclosporine and topical anthralin is effective in patients who are slow to respond to cyclosporine alone.

References

Jun 1, 1990·The British Journal of Dermatology·M M MeinardiJ D Bos
Jun 1, 1990·The British Journal of Dermatology·J F Borel
Jan 1, 1984·Journal of the American Academy of Dermatology·N J LoweH Schaefer
Apr 1, 1994·Journal of the American Academy of Dermatology·B J Nickoloff, Y Naidu

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Citations

Feb 28, 2004·Journal of the American Academy of Dermatology·Mark LebwohlSteven R Feldman
Oct 6, 1997·Clinics in Dermatology·G Mahrle
Nov 26, 2010·Journal of the American Academy of Dermatology·Karrie T AmorAlan Menter
Mar 24, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ulrich MrowietzThomas Werfel
Sep 28, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Silja Domm, Ulrich Mrowietz
Jul 14, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·T M PereiraA Sousa-Basto
Aug 10, 2000·The Journal of Dermatology·T YamamotoK Nishioka
Jan 24, 2006·The Journal of Dermatological Treatment·John Berth-Jones
Feb 1, 1997·Contact Dermatitis·A C de Groot, P J Frosch
Apr 21, 1999·The Journal of Dermatology·A OzawaH Ogawa
May 3, 2021·International Journal of Pediatric Otorhinolaryngology·Tankut UzunErdost Yıldız

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