Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.

Chemistry : a European Journal
Christopher A Brown, Varinder K Aggarwal

Abstract

Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17% overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.

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Citations

Apr 12, 2017·Chemical Communications : Chem Comm·Christopher Sandford, Varinder K Aggarwal
Feb 6, 2017·Bioorganic & Medicinal Chemistry Letters·Vaddela Sudheer BabuYoshito Kishi
Jul 28, 2016·Organic & Biomolecular Chemistry·Vittorio PaceLaura Castoldi
Aug 9, 2016·Chemical Communications : Chem Comm·Viktoria H Gessner
Sep 6, 2017·Organic & Biomolecular Chemistry·Sarah Saint-AuretNicolas Blanchard
Sep 15, 2017·Beilstein Journal of Organic Chemistry·Matthias Gehringer, Karl-Heinz Altmann
Jan 18, 2017·Angewandte Chemie·Ana VarelaVarinder K Aggarwal
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Methods Mentioned

BETA
NMR

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