PMID: 26332797DOI: 10.1002/chem.201503122Sep 4, 2015Paper
Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.
Chemistry : a European Journal
Christopher A Brown, Varinder K Aggarwal
Abstract
Using iterative lithiation-borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17% overall yield. The rapid build-up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.
References
Jan 14, 1999·The American Journal of Tropical Medicine and Hygiene·K Asiedu, S Etuaful
Feb 5, 1999·Science·K M GeorgeP L Small
Jan 20, 2000·Infection and Immunity·K M GeorgeP L Small
Jul 18, 2001·Journal of the American Chemical Society·A B BenowitzY Kishi
Oct 11, 2001·Journal of the American Chemical Society·S FidanzeY Kishi
Dec 26, 2001·FEMS Microbiology Letters·L D CadapanP Licari
Jan 24, 2003·Infection and Immunity·Armand Mve-ObiangP L C Small
Apr 21, 2005·PLoS Medicine·Paul D R JohnsonKingsley Asiedu
May 24, 2005·Infection and Immunity·Armand Mve-ObiangP L C Small
Jun 15, 2005·Cellular Microbiology·Laurent MarsollierStewart T Cole
Jul 7, 2005·Organic & Biomolecular Chemistry·Ruben P van SummerenAdriaan J Minnaard
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·S EtuafulM Wansbrough-Jones
Aug 23, 2005·Chemical Communications : Chem Comm·Hui HongPeter F Leadlay
Mar 25, 2006·Angewandte Chemie·Ning YinEiichi Negishi
Apr 25, 2006·The Lancet Infectious Diseases·Vinciane SizaireFrançoise Portaels
Jun 7, 2006·Lancet·Mark Wansbrough-Jones, Richard Phillips
Aug 23, 2006·Infection and Immunity·Brian S RangerP L C Small
May 29, 2007·Antimicrobial Agents and Chemotherapy·Annick ChautyJacques Grosset
Jul 31, 2007·Angewandte Chemie·Jake L StymiestVarinder K Aggarwal
Oct 18, 2007·Tetrahedron·Fengbin SongYoshito Kishi
Aug 30, 2008·The Journal of Organic Chemistry·Vivek Polshettiwar, Rajender S Varma
Oct 7, 2008·Applied and Environmental Microbiology·Lydia MosiP L C Small
May 14, 2009·Angewandte Chemie·Guillaume DutheuilVarinder K Aggarwal
Feb 9, 2010·Lancet·Willemien A NienhuisTjip S van der Werf
Feb 18, 2010·Chemical Communications : Chem Comm·Thomas Spangenberg, Yoshito Kishi
Mar 17, 2010·Tetrahedron·Katrina L JacksonYoshito Kishi
Jun 23, 2010·Antimicrobial Agents and Chemotherapy·Fred Stephen SarfoM Wansbrough-Jones
Jan 26, 2011·Chemical Communications : Chem Comm·Hye Ryung Kim, Jaesook Yun
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yoshito Kishi
Mar 18, 2011·Chemistry : a European Journal·Guangwei WangEi-ichi Negishi
Oct 6, 2011·Chemistry : a European Journal·Philipp GersbachKarl-Heinz Altmann
Dec 1, 2011·Chemistry : a European Journal·Anne-Caroline ChanyNicolas Blanchard
Apr 17, 2012·Journal of the American Chemical Society·Abraham L MoureJuan C Carretero
Apr 25, 2012·Journal of the American Chemical Society·Alexander P Pulis, Varinder K Aggarwal
Nov 7, 2012·Angewandte Chemie·Matthew J HesseVarinder K Aggarwal
Jan 29, 2013·Angewandte Chemie·Catherine J FletcherVarinder K Aggarwal
Apr 4, 2013·The Journal of Clinical Investigation·Laure Guenin-MacéCaroline Demangel
Apr 5, 2013·PLoS Neglected Tropical Diseases·Nicole ScherrGerd Pluschke
Nov 2, 2013·Natural Product Reports·Anne-Caroline ChanyNicolas Blanchard
Mar 19, 2014·Angewandte Chemie·Alexander P PulisVarinder K Aggarwal
Apr 5, 2014·PLoS Pathogens·Belinda S HallRachel E Simmonds
Apr 24, 2014·Angewandte Chemie·Daniel J BlairVarinder K Aggarwal
Jun 21, 2014·Cell·Estelle MarionPriscille Brodin
Aug 27, 2014·Journal of Medicinal Chemistry·Anne-Caroline ChanyNicolas Blanchard
Sep 12, 2014·Nature·Matthew BurnsVarinder K Aggarwal
Sep 30, 2014·Accounts of Chemical Research·Daniele Leonori, Varinder K Aggarwal
Jan 28, 2015·Journal of the American Chemical Society·Sebastien BalieuVarinder K Aggarwal
Jun 1, 2014·International Journal of Mycobacteriology·Estelle MarionLaurent Marsollier
❮ Previous
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Citations
Apr 12, 2017·Chemical Communications : Chem Comm·Christopher Sandford, Varinder K Aggarwal
Jan 15, 2016·Angewandte Chemie·Alba MillánVarinder K Aggarwal
Oct 27, 2016·Angewandte Chemie·Alexander FawcettVarinder K Aggarwal
Feb 6, 2017·Bioorganic & Medicinal Chemistry Letters·Vaddela Sudheer BabuYoshito Kishi
Jul 28, 2016·Organic & Biomolecular Chemistry·Vittorio PaceLaura Castoldi
Aug 9, 2016·Chemical Communications : Chem Comm·Viktoria H Gessner
Sep 6, 2017·Organic & Biomolecular Chemistry·Sarah Saint-AuretNicolas Blanchard
Feb 11, 2016·PloS One·Jack W Scannell, Jim Bosley
Sep 15, 2017·Beilstein Journal of Organic Chemistry·Matthias Gehringer, Karl-Heinz Altmann
Jan 18, 2017·Angewandte Chemie·Ana VarelaVarinder K Aggarwal
Nov 20, 2016·Angewandte Chemie·Adam NobleVarinder K Aggarwal
Nov 21, 2017·Chemistry : a European Journal·Alba MillánVarinder K Aggarwal
Jul 7, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Vittorio PaceNorbert De Kimpe
Nov 2, 2021·Organic Letters·Zhengwen XueYefeng Tang
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Methods Mentioned
BETA
NMR
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