Short-course carbon-ion radiotherapy for hepatocellular carcinoma: A multi-institutional retrospective study

Liver International : Official Journal of the International Association for the Study of the Liver
Kei ShibuyaJapan Carbon Ion Radiotherapy Study Group

Abstract

Carbon-ion radiation therapy has shown encouraging results in hepatocellular carcinoma patients in single-centre studies. We evaluated the effectiveness and safety of short-course carbon-ion radiation therapy for hepatocellular carcinoma in a multicentre study conducted by the Japan Carbon Ion Radiation Oncology Study Group. Consecutive hepatocellular carcinoma patients who were treated with carbon-ion radiation therapy in four or fewer fractions at four Japanese institutions between April 2005 and November 2014 were analysed retrospectively. The primary outcome was overall survival; secondary outcomes were local control rate, treatment-related toxicity and radiation-induced liver disease. A total of 174 patients were included in this study. Prescribed carbon-ion radiation therapy doses were (relative biological effectiveness): 48.0 Gy in two fractions (n = 46), and 52.8 Gy (n = 108) and 60.0 Gy (n = 20) in four fractions. The median follow-up period was 20.3 (range, 2.9-103.5) months. The overall survival and local control rates at 1, 2 and 3 years were 95.4%, 82.5% and 73.3%; and 94.6%, 87.7% and 81.0% respectively. Multivariate analysis revealed that Eastern Cooperative Oncology Group performance status 1-2, Child-Pugh class...Continue Reading

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·T S LawrenceL F Fajardo
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·S MinoharaM Kanazawa
Aug 27, 2002·Radiation Protection Dosimetry·S KoikeK Nojima
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Hirotoshi KatoUNKNOWN Liver Cancer Working Group
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitsuhiko KawashimaTakashi Ogino
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toshiya ChibaYasuyuki Akine
Feb 5, 2008·International Journal of Radiation Oncology, Biology, Physics·Masashi MizumotoManabu Minami
Jul 1, 2008·Journal of the American College of Surgeons·Vincent Wai-To LamRonnie T P Poon
Mar 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Nobuyoshi FukumitsuKoichi Tokuuye
Sep 4, 2009·International Journal of Radiation Biology·Koichi Ando, Yuki Kase
Jun 29, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hiroshi ImadaHirohiko Tsujii
Oct 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Masashi MizumotoHideyuki Sakurai
Sep 24, 2011·Seminars in Radiation Oncology·Heath D SkinnerSunil Krishnan
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Aug 10, 2013·Journal of Gastroenterology and Hepatology·Atsuya TakedaEtsuo Kunieda
Nov 22, 2014·The Cancer Journal·Matthias UhlJürgen Debus
Feb 2, 2015·The Lancet Oncology·Tadashi KamadaWilliam T Chu
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Oct 12, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yukari YoshidaTakashi Nakano
Dec 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theodore S HongAndrew X Zhu
Mar 13, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi KudoYutaka Matsuyama

❮ Previous
Next ❯

Citations

Nov 28, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Leonardo G Da Fonseca, Alejandro Forner
Mar 3, 2020·Frontiers in Oncology·Timothy D MalouffDaniel Michael Trifiletti
Aug 23, 2019·World Journal of Gastrointestinal Oncology·Che-Yu HsuSung-Hsin Kuo
Apr 14, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Osamu ShibataShuji Terai
Feb 5, 2021·Journal of Cancer Research and Clinical Oncology·Cyrill WehlingMarkus Mieth
Dec 23, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shohei OkazakiTatsuya Ohno
Jun 3, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Charalampos KalantzopoulosGuido Baroni
Oct 19, 2020·Zeitschrift für medizinische Physik·Giorgia MeschiniGuido Baroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.