PMID: 9655533Jul 9, 1998Paper

Short course therapy with cefuroxime axetil for group A streptococcal tonsillopharyngitis in children

The Pediatric Infectious Disease Journal
S MehraH Staley

Abstract

Tonsillopharyngitis caused by group A beta-hemolytic streptococci (GABHS) is common in pediatric clinical practice. Standard penicillin therapy may be associated with poor compliance, penicillin tolerance in GABHS and microbial copathogenicity. Alternative treatments are available (e.g. oral cephalosporins), and data suggest that shorter courses of these agents may be effective. This open, randomized, multicenter study compared a conventional 10-day course of the broad spectrum oral cephalosporin, cefuroxime axetil, with a shorter 5-day course. Cefuroxime axetil suspension, 10 mg/kg, was given twice daily to children (ages 3 to 13 years) screened for GABHS tonsillopharyngitis. Patients were assessed clinically and bacteriologically 4 to 7 days after completing the course and followed up at 21 to 28 days. Among 651 patients recruited 520 had throat cultures positive for GABHS and were randomized to treatment. In the 406 patients with microbiologically confirmed GABHS infection, eradication of the initial pathogen was recorded in 177 of 201 (88%) and 189 of 205 (92%) of patients in the 5- and 10-day groups, respectively, at posttreatment. At follow-up, 137 of 162 (85%) of patients in the 5-day group and 145 of 167 (87%) in the 10...Continue Reading

References

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Citations

Dec 19, 2000·International Journal of Antimicrobial Agents·S Esposito, T Ascione
Jul 20, 2002·International Journal of Antimicrobial Agents·Susanna EspositoUNKNOWN Short Therapy Study Group
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alan L BisnoUNKNOWN Infectious Diseases Society of America
Sep 23, 2000·The Pediatric Infectious Disease Journal·M E Pichichero
Feb 15, 2001·Current Opinion in Pediatrics·M A Gerber, R R Tanz
May 6, 1999·Current Opinion in Pulmonary Medicine·D A MooreJ S Friedland
Sep 14, 2004·The Pediatric Infectious Disease Journal·George A SyrogiannopoulosUNKNOWN Hellenic Antibiotic-Resistant Respiratory Pathogens Study Group
Oct 13, 2005·The Pediatric Infectious Disease Journal·Janet R Casey, Michael E Pichichero
Dec 21, 2004·Treatments in Respiratory Medicine·Wolfgang Elies, Kora Huber
Feb 13, 2007·Diagnostic Microbiology and Infectious Disease·Janet R Casey, Michael E Pichichero
Nov 7, 2003·Clinical Pediatrics·Stan L Block

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