Short day lengths augment stress-induced leukocyte trafficking and stress-induced enhancement of skin immune function

Proceedings of the National Academy of Sciences of the United States of America
Staci D BilboRandy J Nelson

Abstract

Environmental conditions influence the onset and severity of infection and disease. Stressful conditions during winter may weaken immune function and further compromise survival by means of hypothermia, starvation, or shock. To test the hypothesis that animals may use photoperiod to anticipate the onset of seasonal stressors and adjust immune function, we evaluated glucocorticoids and the distribution of blood leukocytes in Siberian hamsters (Phodopus sungorus) exposed to long day lengths (i.e., summer) or short day (SD) lengths (i.e., winter) at baseline and during acute stress. We also investigated the influence of photoperiod and acute stress on a delayed-type hypersensitivity response in the skin. SDs increased glucocorticoid concentrations and the absolute number of circulating blood leukocytes, lymphocytes, T cells, and natural killer cells at baseline in hamsters. During stressful challenges, it appears beneficial for immune cells to exit the blood and move to primary immune defense areas such as the skin, in preparation for potential injury or infection. Acute (2 h) restraint stress induced trafficking of lymphocytes and monocytes out of the blood. This trafficking occurred more rapidly in SDs compared to long days. Bas...Continue Reading

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Citations

Feb 24, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Deborah M BuehlerB Irene Tieleman
Feb 16, 2008·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Lynn B MartinRandy J Nelson
Oct 13, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Timothy J GreivesGregory E Demas
Mar 25, 2004·Trends in Immunology·Randy J Nelson
Feb 11, 2003·Physiology & Behavior·Steven G KinseyRandy J Nelson
Oct 30, 2003·Brain, Behavior, and Immunity·Staci D Bilbo, Randy J Nelson
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zachary M WeilRandy J Nelson
Feb 15, 2013·Proceedings. Biological Sciences·Christine R LattinL Michael Romero
Jul 20, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lynn B MartinRandy J Nelson
Feb 22, 2005·Journal of Neuroendocrinology·B J PrendergastR J Nelson
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Dec 19, 2012·Clinics in Dermatology·Firdaus S Dhabhar
Nov 22, 2007·Ecology·Lynn B MartinRandy J Nelson
Sep 3, 2010·Veterinary Immunology and Immunopathology·Sarah J NebzydoskiTanya F Gressley
Jan 20, 2010·Mutation Research·Carmel Mothersill, Colin Seymour
Mar 26, 2009·General and Comparative Endocrinology·Lynn B Martin
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May 7, 2014·Immunologic Research·Firdaus S Dhabhar
Jun 10, 2003·Annals of the New York Academy of Sciences·Firdaus S Dhabhar
Sep 13, 2003·Journal of Neuroendocrinology·S D BilboR J Nelson
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Feb 22, 2005·Psychoneuroendocrinology·Brian J Prendergast, Randy J Nelson
Dec 23, 2004·General and Comparative Endocrinology·Lynn B Martin IiMartin Wikelski

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