PMID: 8792393Jun 1, 1996Paper

Short dialyzed children respond less to growth hormone than patients prior to dialysis. German Study Group for Growth Hormone Treatment in Chronic Renal Failure

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
E WühlO Mehls

Abstract

Recombinant human growth hormone (rhGH) is a new treatment modality for short children with chronic renal failure (CRF) prior to and during dialysis. It is difficult to analyze whether dialysis patients respond less to rhGH than children with CRF on conservative treatment because they are older and often in a pubertal age range. One hundred and eight patients were treated with 28-30 IU rhGH/kg per week for at least 1 year. We analyzed the growth response to rhGH in 56 prepubertal patients aged less than 10 years at the start of rhGH treatment; 38 children with a mean age of 6.5 +/- 2.4 years were on conservative treatment (CT) and 18 patients with a mean age of 6.5 +/- 2 years on dialysis treatment (D). Mean height velocity was 4.9 +/- 2.3 cm/year in children on CT and 4.6 +/- 1.8 cm/year in children on D. During the 1st treatment year, height velocity was 9.5 +/- 3.8 cm/year in CT patients and 7.3 +/- 1.3 cm/year in D patients (P < 0.05). The change in height was +1.1 +/- 0.8 standard deviation (SD) in CT patients and +0.5 +/- 0.4 SD in D patients (P < 0.005). During the 2nd treatment year, the change in height was again greater in CT patients (0.5 +/- 0.4 SD vs. 0.2 +/- 0.4 SD; P < 0.05). The difference in height velocity and...Continue Reading

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Citations

Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Burkhard TönshoffSonia Ciarmatori
Mar 10, 2007·International Urology and Nephrology·Mohamed A BakrMohamed A Ghoneim
Sep 29, 2011·Nature Reviews. Nephrology·Franz Schaefer, Bradley A Warady
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Elisabeth M HodsonJonathan C Craig
Feb 27, 2015·Clinical and Experimental Nephrology·Yuko HamasakiMasataka Honda
Mar 27, 2004·Endocrinology·Cheryl P Sanchez, Yu-Zhu He
Jul 16, 2008·Acta Paediatrica·O MehlsD Haffner
Jun 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L Rees, H Maxwell
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B D Kuizon, I B Salusky
Mar 24, 2004·Paediatric Drugs·Mark HarrisWayne S Cutfield
Oct 16, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gregory GormanAlicia Neu
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John D MahanUNKNOWN Consensus Committee
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Richard NisselUNKNOWN Pfizer International Growth Database (KIGS) International Board
May 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jutta MuscheitesDieter Haffner
Sep 16, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees
Jun 15, 2019·Nature Reviews. Nephrology·Jens DrubeUNKNOWN European Society for Paediatric Nephrology Chronic Kidney Disease Mineral and Bone Disorders, Dialysis, and Transplantation
Dec 17, 2009·The Journal of Clinical Endocrinology and Metabolism·Otto MehlsMichael B Ranke
Jul 27, 2011·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Eleonora Moreira LimaUNKNOWN Sociedade Brasileira de Nefrologia
Nov 10, 2000·Advances in Renal Replacement Therapy·J T Flynn, B A Warady
Jan 20, 2004·Seminars in Nephrology·Isidro B SaluskyHarald Jüppner
Apr 17, 2004·Kidney International·Cheryl P SanchezNorman J Wilsman
Oct 6, 2021·Indian Journal of Pediatrics·Varuna Vyas, Ram K Menon

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