Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes.

PloS One
Ramkumar MenonR N Taylor

Abstract

Rupture of the fetal membranes is a common harbinger of imminent labor and delivery. Telomere shortening is a surrogate for oxidative stress (OS) and senescence. Fetal leukocyte and placental membrane DNA telomere lengths were evaluated to determine their association with preterm prelabor rupture of the membranes (pPROM) or spontaneous preterm births with intact membranes (PTB), compared to term birth. Telomere lengths were quantified in cord blood leukocytes (n = 133) from three major groups: 1) pPROM (n = 28), 2) PTB (n = 69) and 3) uncomplicated full term births (controls, n = 35), using real-time quantitative PCR. Placental membrane specimens (n = 18) were used to correlate fetal leukocyte and placental telomere lengths. Telomere length differences among the groups were analyzed by ANOVA. Pearson correlation coefficients determined relationships between leukocyte and placental membrane telomere lengths. In pregnancies with intact membranes, fetal leukocyte telomere length was inversely proportional to gestational age. The mean telomere length decreased as gestation progressed, with the shortest at term. pPROM had telomere lengths (9962 ± 3124 bp) that were significantly shorter than gestational age-matched PTB (11546 ± 4348...Continue Reading

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Citations

Aug 28, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyPeter Celec
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Jul 17, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyCtirad Andrys
May 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyCtirad Andrys
Jul 3, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ishraq DhaifalahMarian Kacerovsky
May 26, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca FerrariRamkumar Menon
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Sep 28, 2015·American Journal of Obstetrics and Gynecology·Amy P Murtha, Ramkumar Menon
May 31, 2015·American Journal of Obstetrics and Gynecology·Faranak BehniaRamkumar Menon
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Nov 28, 2014·Frontiers in Immunology·Ramkumar Menon
Sep 24, 2015·PloS One·Jossimara PolettiniRamkumar Menon
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Jan 5, 2014·PloS One·Ramkumar MenonRobert N Taylor
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Jun 22, 2016·The Journal of Endocrinology·Michael C Velarde, Ramkumar Menon
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Jul 3, 2015·Reproductive Sciences·Mark Phillippe
Apr 24, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Isabel Cristina Ribas WerlangMariana Bohns Michalowski
Feb 9, 2018·Molecular Cytogenetics·Nataliya HuleyukMiroslaw Tyrka
Feb 13, 2020·Reproductive Sciences·Brunna Nepomuceno ColattoJossimara Polettini
May 21, 2015·PloS One·Marian KacerovskyJana Nekvindova
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Aug 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alison J EastmanDavid M Aronoff
Jul 28, 2016·Expert Opinion on Therapeutic Targets·Ramkumar Menon, John Papaconstantinou

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Methods Mentioned

BETA
PCR

Software Mentioned

SAS

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