Short hairpin RNA-mediated inhibition of S100A4 promotes apoptosis and suppresses proliferation of BGC823 gastric cancer cells in vitro and in vivo
Abstract
S100A4 has been found to be over-expressed in gastric cancer and associated with poor prognosis of the patients, yet the exact role and molecular mechanism of S100A4 in gastric cancer has not been determined. We found that S100A4 inhibition by RNAi lead to reduced proliferation and increased apoptosis of gastric cancer cell line BGC823. Intratumoral injection of pS100A4-shRNA suppressed tumor growth in nude mice. We also found that S100A4 inhibition decreased the expression of both NF-kappaB p65 and phospho(Ser32)-I-kappaB-alpha. Our results suggested that S100A4 may be an attractive candidate for the therapeutic targeting of gastric cancer.
References
Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma
Citations
Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer
Single-Cell Multimodal Analytical Approach by Integrating Raman Optical Tweezers and RNA Sequencing.
Related Concepts
Related Feeds
Apoptosis
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis
Apoptosis in Cancer
Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.