Short ischemia induces rat kidney mitochondria dysfunction

Journal of Bioenergetics and Biomembranes
Rasa BanieneSonata Trumbeckaite

Abstract

Renal artery clamping itself induces renal ischemia which subsequently causes renal cell injury and can lead to renal failure. The duration of warm ischemia that would be safe for postoperative kidney function during partial nephrectomy remains under investigations. Mitochondria play an important role in pathophysiology of ischemia-reperfusion induced kidney injury, however relation between ischemia time and mitochondrial dysfunction are not fully elucidated. Thus, the effects of renal ischemia (20 min, 40 min and 60 min) on mitochondrial functions were investigated by using in vitro rat ischemia model. Thus, electronmicroscopy showed that at short (20 min) ischemia mitochondria start to swell and the damage increases with the duration of ischemia. In accordance with this, a significant decrease in mitochondrial oxidative phosphorylation capacity was observed already after 20 min of ischemia with both, complex I dependent substrate glutamate/malate (52%) and complex II dependent substrate succinate (44%) which further decreased with the prolonged time of ischemia. The diminished state 3 respiration rate was associated with the decrease in mitochondrial Complex I activity and the release of cytochrome c. Mitochondrial Ca(2+) upt...Continue Reading

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Citations

Jun 24, 2017·Journal of Cellular and Molecular Medicine·Marilena GregoriniTeresa Rampino
Feb 28, 2020·Biomolecules·Miguel Fontecha-BarriusoAna Belen Sanz
Sep 9, 2017·Oxidative Medicine and Cellular Longevity·Sonata TrumbeckaiteRasa Baniene
Mar 14, 2019·The Journal of Pharmacy and Pharmacology·Ivan Sergeevich MokrousovIvan Nikolaevich Tyurenkov
Oct 27, 2020·BioMed Research International·Justina KamarauskaiteSonata Trumbeckaite
Jul 3, 2021·International Journal of Molecular Sciences·Lucy BirtwistleCarol Pollock
Jun 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Najet Hadj AbdallahHassen Ben Abdennebi

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