Short latency afferent inhibition and facilitation in patients with writer's cramp

Movement Disorders : Official Journal of the Movement Disorder Society
Kirn R KesslerU Ziemann

Abstract

Patients with writer's cramp (WC) show abnormalities of sensorimotor integration possibly contributing to their motor deficit. We studied sensorimotor integration by determining short-latency afferent inhibition (SAI) in 12 WC patients and 10 age-matched healthy controls. A conditioning electrical median nerve stimulus was followed 14 to 36 msec later by transcranial magnetic stimulation of the contralateral primary motor cortex, and motor evoked potentials (MEP) were recorded from the relaxed or contracting abductor pollicis brevis muscle (APB). SAI was normal in WC but during APB relaxation SAI was followed by abnormal MEP facilitation, which was absent during APB contraction and in the controls. These findings suggest that somatosensory short-latency inhibitory input into the primary motor cortex is normal in WC, whereas a later excitatory input, which very likely reflects the long-latency reflex II, is exaggerated.

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Citations

Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Allan D WuAlvaro Pascual-Leone
Aug 20, 2009·Brain : a Journal of Neurology·A QuartaroneJ C Rothwell
Sep 22, 2011·Brain : a Journal of Neurology·Maria StamelouKailash P Bhatia
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Apr 29, 2014·Current Neurology and Neuroscience Reports·Aparna Wagle Shukla, David E Vaillancourt
Feb 15, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Emma BurnsSiobhan May Schabrun
Aug 1, 2015·Journal of Neural Transmission·Marina PicilloFiore Manganelli
Apr 13, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Eungseok OhWooyoung Jang
Jul 5, 2008·The Journal of Physiology·François D Roy, Monica A Gorassini
Jan 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Laura AvanzinoJohn C Rothwell
Nov 8, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Tobias BäumerAlexander Münchau
Dec 7, 2007·Muscle & Nerve·Sarah Pirio RichardsonMark Hallett
Nov 1, 2011·The European Journal of Neuroscience·Ashleigh E SmithJulia B Pitcher
Jan 29, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Anna SadnickaMark Edwards
Apr 17, 2015·The European Journal of Neuroscience·Luigi TamèKaren T Reilly
Apr 4, 2015·The Journal of Physiology·Robin F H CashRobert Chen
Aug 15, 2017·Journal of Neural Transmission·Raffaele NardoneLuca Sebastianelli
Apr 7, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Maja KojovicMark J Edwards

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