Short linear cationic antimicrobial peptides: screening, optimizing, and prediction

Methods in Molecular Biology
Kai HilpertArtem Cherkasov

Abstract

The problem of pathogenic antibiotic-resistant bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa is worsening, demonstrating the urgent need for new therapeutics that are effective against multidrug-resistant bacteria. One potential class of substances is cationic antimicrobial peptides. More than 1000 natural occurring peptides have been described so far. These peptides are short (less than 50 amino acids long), cationic, amphiphilic, demonstrate different three-dimensional structures, and appear to have different modes of action. A new screening assay was developed to characterize and optimize short antimicrobial peptides. This assay is based on peptides synthesized on cellulose, combined with a bacterium, where a luminescence gene cassette was introduced. With help of this method tens of thousands of peptides can be screened per year. Information gained by this high-throughput screening can be used in quantitative structure-activity relationships (QSAR) analysis. QSAR analysis attempts to correlate chemical structure to measurement of biological activity using statistical methods. QSAR modeling of antimicrobial peptides to date has been based on predicting differences between peptides that are highly similar....Continue Reading

Citations

Feb 2, 2011·Antimicrobial Agents and Chemotherapy·E C SpindlerR T Gill
Jul 5, 2011·Journal of Bacteriology·Albert F EllenArnold J M Driessen
Jul 9, 2011·PloS One·Carlos Polanco GonzálezGabriel del Rio
Jan 27, 2017·Molecular Informatics·Petra SchneiderGisbert Schneider
Jan 29, 2011·European Biophysics Journal : EBJ·Davor JuretićAlessandro Tossi
Feb 11, 2020·Frontiers in Microbiology·Marlon H CardosoOctávio L Franco
Nov 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ernest Y LeeAndrew L Ferguson
Nov 15, 2011·Critical Reviews in Biotechnology·Mukesh PasupuletiMartin Malmsten
May 17, 2019·Current Opinion in Colloid & Interface Science·Michelle W LeeGerard C L Wong
Sep 4, 2015·Journal of Chemical Information and Modeling·Mara KozićDavor Juretić
Oct 26, 2012·Journal of Chemical Information and Modeling·Nédia KamechDavor Juretić
May 18, 2018·Bioconjugate Chemistry·Michelle W LeeGerard C L Wong
Sep 6, 2014·Molecular Pharmaceutics·Karsten RapschMarkus von Nickisch-Rosenegk
Jun 11, 2011·Insect Biochemistry and Molecular Biology·Norman A RatcliffePatricia Azambuja

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Peptide Science : an Official Publication of the European Peptide Society
T LejonJ S M Svendsen
Journal of Peptide Science : an Official Publication of the European Peptide Society
T LejonJ S M Svendsen
Journal of Agricultural and Food Chemistry
Shuryo NakaiMasahiro Ogawa
Journal of Chemical Information and Computer Sciences
M HosseiniI Spence
© 2022 Meta ULC. All rights reserved